{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:09Z","timestamp":1787383389209,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To compare the effects of loteprednol etobonate (LE) and ketorolac tromethamine (KT) on pupil diameter (PD) and aqueous humor levels of prostaglandin E\n                      <jats:sub>2<\/jats:sub>\n                      (PGE\n                      <jats:sub>2<\/jats:sub>\n                      ), total protein (TP), and glutathione (GSH) following paracentesis\u2010induced intraocular inflammation in cats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty cats (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910\/group) underwent anterior chamber paracentesis at T1 and T2 (60\u2009min apart). At T1, the right eye received one drop of LE, KT, or saline (CG). PD was measured at T1 and T2, and aqueous humor samples were analyzed for PGE\n                      <jats:sub>2<\/jats:sub>\n                      , TP, and GSH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At T1, PD, PGE\n                      <jats:sub>2<\/jats:sub>\n                      , TP, and GSH levels did not differ among groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). At T2, PGE\n                      <jats:sub>2<\/jats:sub>\n                      concentrations were significantly lower in LE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and KT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) groups when compared to CG. When compared to CG, TP values were significantly lower only in the LE group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). GSH levels decreased significantly across all groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), maintaining significantly higher levels in the LE group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). PD decreased significantly in the CG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and KT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) groups, but not in the LE group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.18).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      LE and KT effectively reduced PGE\n                      <jats:sub>2<\/jats:sub>\n                      levels following paracentesis. LE also significantly decreased TP levels, mitigated miosis, and preserved GSH, indicating reduced oxidative stress. Considering that KT also reduced PGE\n                      <jats:sub>2<\/jats:sub>\n                      levels, further studies are warranted to determine whether KT might effectively reduce protein influx into the anterior chamber at later time points.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70020","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T08:58:31Z","timestamp":1744880311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Loteprednol Etabonate and Ketorolac Tromethamine on Intraocular Inflammation and Oxidative Stress After Paracentesis\u2010Induced Blood\u2010Aqueous Barrier Breakdown in Cats"],"prefix":"10.1111","volume":"29","author":[{"given":"Hanna Rodrigues","family":"Miranda","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Mato Grosso  Cuiab\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8922-2886","authenticated-orcid":false,"given":"Alexandre Pinto","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Mato Grosso  Cuiab\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Dumit","family":"Pizzinatto","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Mato Grosso  Cuiab\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Eidt","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Mato Grosso  Cuiab\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"de Assis Pereira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Mato Grosso  Cuiab\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Henrique","family":"de Oliveira Alves","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Mato Grosso  Cuiab\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u00e9lem Aparecida","family":"de Fran\u00e7a Lemes","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Mato Grosso  Cuiab\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"de Oliveira Souza","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Mato Grosso  Cuiab\u00e1 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