{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:50:36Z","timestamp":1778172636207,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To classify evaporative dry eye disease (EDED) in dogs and trial therapies based upon tear film lipid layer thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty client\u2010owned dogs diagnosed with EDED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>\n                      Patients were recruited for retrospective assessment if they were diagnosed with EDED in the absence of other diagnoses that may lead to tear film instability. Tear film interferometry was performed to diagnose a lipid\u2010deficient EDED (LD\u2010EDED; &lt;\u200930\u2009nm) or idiopathic EDED (I\u2010EDED; &gt;\u200930\u2009nm). Dogs with LD\u2010EDED were treated with combined topical paraffin and wool fat ointment and oral flaxseed oil. Dogs with I\u2010EDED were treated with combined topical trehalose and hyaluronic acid drops and either topical compounded tacrolimus or cyclosporine. A TFBUT was performed a minimum of 4\u2009weeks later, and these were compared pre\u2010 and posttreatment via paired student\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests and linear regression analysis with Pearson's correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with LD\u2010EDED had a significant and strong correlation between pretreatment lipid layer thickness and pretreatment TFBUT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). Total mean pre\u2010 and posttreatment TFBUT was 3.63\u2009\u00b1\u20092.48 and 10.79\u2009\u00b1\u20094.83\u2009s (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) seconds, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). LD\u2010EDED pre\u2010 and posttreatment TFBUT was 3.75\u2009\u00b1\u20093.05\u2009s and 11.75\u2009\u00b1\u20093.98\u2009s (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients with I\u2010EDED had a pre\u2010 and posttreatment TFBUT of 3.56\u2009\u00b1\u20092.63\u2009s and 9.76\u2009\u00b1\u20094.32\u2009s, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dogs with EDED appear to have significantly longer TFBUT following directed therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70079","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T05:44:48Z","timestamp":1757742288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treating Evaporative Dry Eye Disease in Dogs Based Upon Tear Film Lipid\u2010Layer Thickness: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"29","author":[{"given":"Benjamin D.","family":"Reynolds","sequence":"first","affiliation":[{"name":"Eye Clinic for Animals  Sydney New South Wales Australia"},{"name":"Las Vegas Veterinary Specialty Center  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Whittaker","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly A.","family":"Caruso","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-4508","authenticated-orcid":false,"given":"William M.","family":"Irving","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(77)90087-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(90)50071-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-84782008000200048"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-2203-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13066"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1984.45.01.112"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.12.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13044"},{"key":"e_1_2_9_11_1","first-page":"3348","article-title":"The Thickness of the Human Precorneal Tear Film: Evidence From Reflection Spectra","volume":"41","author":"King\u2010Smith P. 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