{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:50:48Z","timestamp":1785883848772,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009944","name":"American College of Veterinary Ophthalmologists Vision for Animals Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD018221"],"award-info":[{"award-number":["S10 OD018221"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["100010434"],"award-info":[{"award-number":["100010434"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the relationship between increased intraocular pressure (IOP) and the structure of the post\u2010trabecular aqueous outflow tract of dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ex vivo aqueous angiography (AA) and anterior segment optical coherence tomography (OCT) were performed concurrently in 19 normal canine eyes, following cannulation and intracameral infusion of 2.5% fluorescein and\/or indocyanine green (ICG) after maintaining eyes at physiologic IOP (10\u201325\u2009mmHg) for 30\u2009min and\/or elevated IOP (55\u201368\u2009mmHg) for 30 or 120\u2009min. Scleral lumen heights (SLH) of vascular profiles in OCT scans were measured by Image J, and values analyzed in linear regression models. In a subset of 10 eyes, each quadrant was subjectively characterized as being either a high\u2010flow or low\u2010flow region based on angiographic signal intensity at 2 or 10\u2009min post\u2010tracer infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Segmental AA outflow signal correlated with lumens seen on OCT scleral line scans in healthy canine eyes at physiologic IOP. These lumens were also observed at elevated IOP but appeared collapsed in profile. After both 30 and 120\u2009min of IOP elevation, SLH was significantly reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Large vessels tended to collapse more than small vessels after IOP elevation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute IOP elevation resulted in a significant reduction in SLH in healthy canine eyes, and the number of AA determined high flow regions was reduced. Future studies to understand the nature and timing of this pressure\u2010dependent change in the post\u2010trabecular outflow pathway in glaucomatous eyes, including its potential reversibility, will be crucial in developing novel diagnostic tools and treatments for canine glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70080","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T03:49:47Z","timestamp":1758599387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging Canine Post\u2010Trabecular Aqueous Outflow Pathways: Effect of Acute Intraocular Pressure Elevation in Normal Eyes"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8203-1274","authenticated-orcid":false,"given":"Odalys","family":"Torn\u00e9","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Nilles","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison 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