{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:30:55Z","timestamp":1774848655905,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the stability of two ophthalmic gels\u2014one containing carbomer alone (Ocry\u2010gel), and the other combining carbomer with sodium hyaluronate (Eye Lube Pro)\u2014on the corneal surface of anesthetized dogs, using spectral\u2010domain optical coherence tomography (SD\u2010OCT) to quantify Central Tear Film Thickness (CTFT) over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty healthy dogs undergoing general anesthesia for non\u2010ocular routine procedures were included in a randomized controlled study. Each dog received Ocry\u2010gel in one eye and Eye Lube Pro in the contralateral eye, according to a randomization protocol. CTFT was measured with ultrahigh\u2010resolution anterior segment SD\u2010OCT before (T0) and after (T1) administration of 200\u2009\u03bcL of each gel, then at 10, 15, 20, 25, 30, 35, 40, 45, 50, and 60\u2009min. CTFT evolution was analyzed by two\u2010way repeated\u2010measures ANOVA with normality testing and non\u2010parametric correction when required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CTFT profiles significantly differed between formulations. Eye Lube Pro exhibited more sustained thickness than Ocry\u2010gel. After 60\u2009min, CTFT remained measurable in 14\/20 dogs for Eye Lube Pro versus 2\/20 for Ocry\u2010gel. Statistical analysis confirmed significantly higher CTFT for Eye Lube Pro at most time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant influence of sex, age, or brachycephalic phenotype was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Addition of sodium hyaluronate to a carbomer\u2010based gel significantly prolongs pre\u2010corneal retention time in anesthetized dogs. These results suggest that selecting the protective gel should consider anesthesia duration or guide adjustment of administration frequency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70109","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:06:12Z","timestamp":1762344372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Measurement of the Retention Time of Two Different Carbomer\u2010Based Ophthalmic Gels With and Without Hyaluronic Acid in Anesthetized Dogs Using Ultrahigh\u2010Resolution Optical Coherence Tomography"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6073-828X","authenticated-orcid":false,"given":"Bertrand","family":"Michaud","sequence":"first","affiliation":[{"name":"Clinique V\u00e9t\u00e9rinaire Anima\u2010Vet  Saint\u2010Genis\u2010Pouilly France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e8s","family":"Desquiens","sequence":"additional","affiliation":[{"name":"Clinique V\u00e9t\u00e9rinaire Anima\u2010Vet  Saint\u2010Genis\u2010Pouilly France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Amiriantz","sequence":"additional","affiliation":[{"name":"D\u00f4mes Pharma  Pont\u2010du\u2010Ch\u00e2teau 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Ultrahigh\u2010Resolution Optical Coherence Tomography","volume":"42","author":"Gagliano C.","year":"2017","journal-title":"Current Eye Research"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12993"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12660"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12150"},{"key":"e_1_2_11_14_1","first-page":"312","article-title":"A Bioinspired Synthetic Soft Hydrogel for the Treatment of Dry Eye","volume":"14","author":"Li J.","year":"2022","journal-title":"Bioactive Materials"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"199","article-title":"The Effect of Periocular Fatty Acids and 0.15% Hyaluronate Eye Drops Application on Keratoconjunctivitis Sicca in Dogs: An Exploratory Study","volume":"26","author":"Santillo D.","year":"2023","journal-title":"Veterinary Ophthalmology"}],"container-title":["Veterinary 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