{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:33:18Z","timestamp":1774848798888,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Osseous metaplasia is a rare condition characterized by abnormal bone growth in soft tissues. Although documented in mammals, intraocular osseous metaplasia is uncommon in avian species and has been poorly characterized in turkeys (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Meleagris gallopavo<\/jats:italic>\n                      <\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>An adult Norfolk Black turkey presented with progressive buphthalmos, caseous ocular discharge, and complete vision loss confined to the left eye. Owing to the poor prognosis, enucleation was performed. Gross examination revealed a friable, caseous, yellow\u2010white intraocular mass with retinal and vitreous involvement. Histopathological examination revealed abundant osteoid matrix and osseous trabeculae, intense neovascularization, heterophilic infiltration, and areas resembling the medullary bone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Histopathological findings support the diagnosis of intraocular osseous metaplasia, which is distinct from normal scleral ossicles in birds. Chronic inflammation and longstanding retinal detachment may trigger differentiation of retinal pigment epithelium (RPE) into osteoblast\u2010like cells, contributing to osseous metaplasia in the ciliary body. Intraocular bone formation in birds remains poorly understood, and further investigation of its pathogenesis is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report describes a well\u2010characterized case of intraocular osseous metaplasia in a turkey. Recognition of this uncommon condition is essential when considering the differential diagnoses of intraocular masses in avian species, emphasizing the diagnostic value of histopathological evaluation. Further studies are warranted to explore the possible systemic involvement and to elucidate the underlying etiologies, including chronic inflammation and trauma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70118","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:50:54Z","timestamp":1764240654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraocular Osseous Metaplasia in Norfolk Black Turkey (\n                    <i>Meleagris gallopavo<\/i>\n                    ): Clinicopathological Characterization of a Rare Avian Condition"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-8143","authenticated-orcid":false,"given":"Taina","family":"dos Santos Alberti","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade de Cruz Alta  Cruz Alta Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-3197","authenticated-orcid":false,"given":"Andressa Trindade","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade de Cruz Alta  Cruz Alta Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6412-9223","authenticated-orcid":false,"given":"Magale Dallaporta","family":"Furquim","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade de Cruz Alta  Cruz Alta Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9248-7851","authenticated-orcid":false,"given":"Driele Fernanda","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade de Cruz Alta  Cruz Alta Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-660X","authenticated-orcid":false,"given":"Rosimeri","family":"Zamboni","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Pelotas UFPel  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-9876","authenticated-orcid":false,"given":"Eliza Simone Vi\u00e9gas","family":"Sallis","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Pelotas UFPel  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5593-3110","authenticated-orcid":false,"given":"Clairton","family":"Marcolongo\u2010Pereira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria, Centro Universit\u00e1rio do Esp\u00edrito Santo UNESC  Colatina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35775-3.00001-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10172"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4076"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"183","article-title":"Intraocular Osseous Metaplasia. 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