{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:49:40Z","timestamp":1785883780666,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009944","name":"American College of Veterinary Ophthalmologists Vision for Animals Foundation","doi-asserted-by":"publisher","award":["VAF2025\u20103"],"award-info":[{"award-number":["VAF2025\u20103"]}],"id":[{"id":"10.13039\/100009944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T35 OD011078"],"award-info":[{"award-number":["T35 OD011078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 EY027721"],"award-info":[{"award-number":["T32 EY027721"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effects of topical prostaglandin E2 receptor 2 (EP2) agonist, omidenepag isopropyl (OMDI), on intraocular pressure (IOP) and pupil diameter (PD) in normal cats and cats with feline congenital glaucoma (FCG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Ten FCG cats and 8 normal cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, randomized, placebo\u2010controlled, masked pilot study, normal and FCG cats received one drop of 0.002% OMDI ophthalmic solution in one eye and artificial tears in the contralateral eye. IOP and PD were measured by a masked observer at baseline and at multiple time points up to 32\u201336\u2009h post\u2010administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Topical 0.002% OMDI significantly lowered IOP compared to controls in both normal and FCG cats. In normal cats, the effect was significant up to 12\u2009h after instillation, with a maximal reduction from baseline of 7.3\u2009mmHg (43.5%). In FCG cats, the effect was significant from 2 to 8\u2009h after instillation, with a maximal reduction from baseline of 16.7\u2009mmHg (60.2%). No significant effect on pupil diameter or signs of ocular irritation was observed in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single topical drop of 0.002% OMDI significantly lowers IOP in normal and FCG cats without inducing miosis. Our findings support that topical selective EP2 agonists may be a promising therapeutic option for feline glaucoma and provide information relevant to dosing intervals for future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70125","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:39:52Z","timestamp":1764751192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Topical Omidenepag Isopropyl Lowers Intraocular Pressure in Normal and Glaucomatous Cats: A Pilot Study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-4786","authenticated-orcid":false,"given":"Kazuya","family":"Oikawa","sequence":"first","affiliation":[{"name":"Surgical Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"McPherson Eye Research Institute  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-2346","authenticated-orcid":false,"given":"Julie A.","family":"Kiland","sequence":"additional","affiliation":[{"name":"Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden G.","family":"Zaluckyj","sequence":"additional","affiliation":[{"name":"Surgical Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Rai","sequence":"additional","affiliation":[{"name":"Surgical Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"McPherson Eye Research Institute  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Mathu","sequence":"additional","affiliation":[{"name":"Surgical Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"McPherson Eye Research Institute  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-7476","authenticated-orcid":false,"given":"Gillian J.","family":"McLellan","sequence":"additional","affiliation":[{"name":"Surgical Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"McPherson Eye Research Institute  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2015.06.010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2008.00614.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154412"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2024.108519"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13302"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12292"},{"key":"e_1_2_13_8_1","first-page":"312","article-title":"Long\u2010Term Maintenance of Reduced Intraocular Pressure by Daily or Twice Daily Topical Application of Prostaglandins to Cat or Rhesus Monkey Eyes","volume":"24","author":"Bito L. 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