{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:24:11Z","timestamp":1788881051309,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Squamous cell carcinoma (SCC) is one of the most common malignant eyelid tumors in cats, especially in white\u2010haired individuals chronically exposed to sunlight. Electrochemotherapy (ECT), which combines bleomycin administration with transient membrane permeabilization through electric pulses, has demonstrated efficacy in periocular epithelial tumors. However, its use as monotherapy for third eyelid SCC has not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the clinical outcomes, feasibility, and safety of ECT as sole treatment for third eyelid SCC in two cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two client\u2010owned cats with histologically confirmed SCC restricted to the third eyelid underwent full staging, including thoracic radiographs and head CT. Both were treated with a single ECT session involving systemic and intratumoral bleomycin followed by electric pulses. Follow\u2010up consisted of clinical and imaging evaluations for up to 930\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both cats achieved complete remission after one session. No recurrence or metastasis was detected during long\u2010term follow\u2010up. Treatment was well tolerated, with only mild, self\u2010limiting inflammation. Ocular structures and function were fully preserved, without systemic toxicity. Owners expressed high satisfaction due to the non\u2010invasive nature of ECT and the avoidance of enucleation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This is the first report of successful ECT monotherapy for feline third eyelid SCC. The findings support ECT as a safe, effective, and organ\u2010sparing option when surgery is declined or contraindicated, highlighting its potential role in feline ocular oncology and comparative oncology. Although promising, the very limited sample size (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) prevents strong conclusions, and results should be regarded as preliminary observational evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70129","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T10:32:08Z","timestamp":1767522728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electrochemotherapy as Monotherapy Provides a Novel, Organ\u2010Sparing, Long Term Treatment Option for Control of Feline Third Eyelid Squamous Cell Carcinoma: A Report of Two Cases"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-3545","authenticated-orcid":false,"given":"S.","family":"Pe\u00f1a","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, Faculty of Veterinary Medicine University of Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"},{"name":"Hospital Cl\u00ednico Veterinario University of Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13586"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12995"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.526"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8120225"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.548"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcsup.2006.08.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08666.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2013.07.019"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41026-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001468"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13193"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.33448\/rsd-v12i10.43516"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12273"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:29:10Z","timestamp":1787380150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vop.70129"],"URL":"https:\/\/doi.org\/10.1111\/vop.70129","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70129"}}