{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:03Z","timestamp":1787383383208,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To assess the effects of a therapeutic dose of oral acetaminophen on Schirmer tear test I (STT\u20101) and intraocular pressure (IOP) in healthy dogs.<\/jats:p>\n <\/jats:sec>\n \n Animals Studied<\/jats:title>\n Fourteen healthy adult beagle dogs.<\/jats:p>\n <\/jats:sec>\n \n Procedures<\/jats:title>\n All animals underwent a physical and ophthalmic examination, hematology, and plasma biochemistry prior to treatment. Oral acetaminophen at 30\u2009mg\/kg every 12\u2009h for 5\u2009days was administered. STT\u20101 and IOP were measured in both eyes before drug administration. Ocular adverse effects were assessed using a semiquantitative preclinical ocular toxicology scoring system. All measurements were performed by the same investigator under controlled environmental conditions. At the end time point, follow\u2010up physical and ophthalmic examinations and blood workup were conducted.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n STT\u20101 remained stable throughout the study, with no significant differences between time points (\n p<\/jats:italic>\n \u2009=\u20090.665) or overall trend over time (\n p<\/jats:italic>\n \u2009=\u20090.356). IOP showed no consistent temporal trend (\n p<\/jats:italic>\n \u2009=\u20090.602), although significant differences were observed between specific time points (\n p<\/jats:italic>\n \u2009=\u20090.003). IOP at 24\u2009h was higher than at 12\u2009h (\n p<\/jats:italic>\n \u2009=\u20090.031) and 60\u2009h (\n p<\/jats:italic>\n \u2009=\u20090.009), and at 0\u2009h compared to 60\u2009h (\n p<\/jats:italic>\n \u2009=\u20090.043); however, these differences were transient and clinically irrelevant (1\u20132\u2009mmHg). Mild conjunctival hyperaemia and fluorescein staining uptake were observed in 3\/28 eyes, although these were mild and resolved spontaneously without treatment. No systemic adverse effects were detected.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Oral therapeutic doses of acetaminophen for 5\u2009days did not affect STT\u20101 or IOP in healthy dogs. Further studies should evaluate its effects in dogs with systemic diseases, pre\u2010existing ocular conditions, or as long\u2010term or multi\u2010drug regimen treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vop.70131","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:40:39Z","timestamp":1768822839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Oral Acetaminophen on Tear Production and Intraocular Pressure in Healthy Dogs"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8143-9034","authenticated-orcid":false,"given":"Anna M.","family":"Mesa","sequence":"first","affiliation":[{"name":"Servicio de Oftalmolog\u00eda, AniCura Valencia Sur Hospital Veterinario Silla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9400-1490","authenticated-orcid":false,"given":"Aloma","family":"Mayordomo\u2010Febrer","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal Facultad de Veterinaria, Universidad Cardenal Herrera\u2010CEU, CEU Universities Alfara del Patriarca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"L\u00f3pez\u2010Murcia","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal Facultad de Veterinaria, Universidad Cardenal Herrera\u2010CEU, CEU Universities Alfara del Patriarca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cerrada","sequence":"additional","affiliation":[{"name":"Servicio de Oftalmolog\u00eda, AniCura Valencia Sur Hospital Veterinario Silla Spain"},{"name":"Servicio de Oftalmolog\u00eda, Hospital Cl\u00ednico Veterinario, Facultad de Veterinaria Universidad Cardenal Herrera\u2010CEU, CEU Universities Alfara del Patriarca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-4617","authenticated-orcid":false,"given":"\u00c1ngel","family":"Ortill\u00e9s","sequence":"additional","affiliation":[{"name":"Servicio de Oftalmolog\u00eda, AniCura Valencia Sur Hospital Veterinario Silla Spain"},{"name":"Servicio de Oftalmolog\u00eda, Hospital Cl\u00ednico Veterinario, Facultad de Veterinaria Universidad Cardenal Herrera\u2010CEU, CEU Universities Alfara del Patriarca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"467","volume-title":"Veterinary Pharmacology and Therapeutics","author":"Lees P.","year":"2018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02764.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105487"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.1058"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223697"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajavsp.2021.247.262"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13566"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-7292"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.76.9.755"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.81.8.627"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11123609"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3181\/0701-RM-19"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90266-7"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"142","article-title":"Acetaminophen Toxicosis in a Dalmatian","volume":"44","author":"MacNaughton S. 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