{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:19Z","timestamp":1787383399265,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the impact of thrice\u2010daily instillation of 0.4% ketorolac trometamol (KT) over 15\u2009days on blood count, serum biochemistry, and urinalysis in healthy cats. Additionally, we tested the efficacy of luminol to detect fecal occult blood (FOB) in feces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A placebo\u2010controlled, randomized study was conducted with 24\u2009healthy cats. In 12 cats, each eye received either 40\u2009\u03bcL of KT or saline (S) every 8\u2009h for 15\u2009days. An additional 12 cats received saline in both eyes and served as controls (S). Baseline blood count, serum biochemical analysis, urinalysis, and FOB testing were performed before the study and after each 15\u2010day treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline blood count, serum biochemistry, and urinary values were within reference limits for both treatments. By day 15, increased cholesterol (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and decreased potassium (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) levels were observed in KT. Despite these changes, all measurements remained within reference limits, except for ALT, which significantly increased at day 15 in KT when compared to baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and S (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). At baseline, all fecal samples from KT and S tested negative for FOB. By day 15, 10 of 12 KT samples tested positive for FOB (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that thrice\u2010daily instillation of KT for 15\u2009days induces a subclinical hepatocellular injury and gastrointestinal bleeding, with potential effects on potassium levels in healthy cats. Luminol proved to be a reliable test for detecting fecal occult blood in the feces of healthy cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70136","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:00:59Z","timestamp":1768399259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Effects of Ocular Instillation of 0.4% Ketorolac Trometamol and Luminol\u2010Based Detection of Fecal Occult Blood in Healthy Cats"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-5938","authenticated-orcid":false,"given":"Matheus Anthony","family":"Mendes","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria Universidade Federal de Mato Grosso  Cuiab\u00e1 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