{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:09Z","timestamp":1787383389159,"version":"build-2736575974"},"reference-count":120,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To determine the in\u00a0vitro antimicrobial activity of specific antiseptics against common equine ocular surface pathogens.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n \n Staphylococcus aureus<\/jats:italic>\n <\/jats:styled-content>\n (\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n ) (\n n<\/jats:italic>\n \u2009=\u200912),\n \n Streptococcus equi<\/jats:italic>\n <\/jats:styled-content>\n subspecies zooepidemicus (\n S. zooepidemicus<\/jats:italic>\n ) (\n n<\/jats:italic>\n \u2009=\u20099),\n \n Enterobacter hormaechei<\/jats:italic>\n <\/jats:styled-content>\n (\n \n E. hormaechei<\/jats:italic>\n <\/jats:styled-content>\n ) (\n n<\/jats:italic>\n \u2009=\u20096), and\n \n Bacillus cereus<\/jats:italic>\n <\/jats:styled-content>\n (\n \n B. cereus<\/jats:italic>\n <\/jats:styled-content>\n ) (\n n<\/jats:italic>\n \u2009=\u20095) were collected from corneal samples of horses with ulcerative keratitis. Reference strains were included. Minimum bactericidal concentrations (MBC) of polyhexanide, povidone\u2010iodine, and hypochlorous acid were tested using the microdilution method. After incubation with the antimicrobial agent, the inocula were subcultured according to the Clinical and Laboratory Standards Institute guidelines. Colony growth was manually counted and photographically documented.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The MBC values of polyhexanide were 0.8\u20133.2\u2009ppm for\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n , 0.8\u20131.6\u2009ppm for S. zooepidemicus, 1.6\u20133.2\u2009ppm for\n \n E. hormaechei<\/jats:italic>\n <\/jats:styled-content>\n , and 1.6\u20136.4\u2009ppm for\n \n B. cereus<\/jats:italic>\n <\/jats:styled-content>\n . For povidone\u2010iodine, values were 8\u201332\u2009ppm for\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n , 4\u201316\u2009ppm for S. zooepidemicus, 8\u201316\u2009ppm for\n \n E. hormaechei<\/jats:italic>\n <\/jats:styled-content>\n , and 8\u201316\u2009ppm for\n \n B. cereus<\/jats:italic>\n <\/jats:styled-content>\n . For hypochlorous acid, values were 0.4\u20136.4\u2009ppm for\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n , 0.4\u20133.2\u2009ppm for S. zooepidemicus, 0.8\u20131.6\u2009ppm for\n \n E. hormaechei<\/jats:italic>\n <\/jats:styled-content>\n , and 1.6\u20136.4\u2009ppm for\n \n B. cereus<\/jats:italic>\n <\/jats:styled-content>\n . The MBC values of methicillin\u2010resistant\n \n S. aureus<\/jats:italic>\n <\/jats:styled-content>\n isolates were comparable to those of methicillin\u2010susceptible isolates.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n All antiseptics are highly efficient against common equine ocular bacterial surface pathogens, in concentrations that are well below those of commercially available products. In accordance with the One Health approach, these findings highlight their potential in treating infectious ocular surface disease either as an alternative or alongside topical antibiotics. Further in\u00a0vivo and clinical studies are required to investigate the translatability of their in\u00a0vitro effectiveness to clinic cases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vop.70141","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:35:09Z","timestamp":1768822509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polyhexanide, Povidone\u2010Iodine, and Hypochlorous Acid Show High In\u00a0Vitro Antimicrobial Efficacy Against Pathogens Commonly Associated With Equine Infectious Keratitis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1542-4101","authenticated-orcid":false,"given":"Leonie Maria","family":"Stolle","sequence":"first","affiliation":[{"name":"Clinic for Horses University of Veterinary Medicine Hannover, Foundation Hannover Lower Saxony Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-4979","authenticated-orcid":false,"given":"Hilke","family":"Oltmanns","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacy University of Veterinary Medicine Hannover, Foundation Hannover Lower Saxony Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7263-848X","authenticated-orcid":false,"given":"Jessica","family":"Mei\u00dfner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacy University of Veterinary Medicine Hannover, Foundation Hannover Lower Saxony Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-3772","authenticated-orcid":false,"given":"Frederik","family":"Heun","sequence":"additional","affiliation":[{"name":"Clinic for Horses University of Veterinary Medicine Hannover, Foundation Hannover Lower Saxony Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kathrin","family":"Schieder","sequence":"additional","affiliation":[{"name":"LABOKLIN GmbH & Co. KG Bad Kissingen Bavaria Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2726-3564","authenticated-orcid":false,"given":"Hinrich T\u00f6njes","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinic for Small Animals University of Veterinary Medicine Hannover, Foundation Hannover Lower Saxony Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ohnesorge","sequence":"additional","affiliation":[{"name":"Clinic for Horses University of Veterinary Medicine Hannover, Foundation Hannover Lower Saxony Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-4195","authenticated-orcid":false,"given":"Claudia","family":"Busse","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinic for Small Animals University of Veterinary Medicine Hannover, Foundation Hannover Lower Saxony Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Equine Ophthalmology","author":"Gilger B. C.","year":"2017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13101"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.20423306.2010.tb05630.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/VMRR.S25013"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.14635224.2012.01004.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2010.00767.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2023.104990"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12480"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12985"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.14059"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.13221"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.13812"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054530731"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12042"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12701"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.2012.00623.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749\u20100739(17)30440\u20106"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2746\/095777308X334266"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2003.00312.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12662"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12833"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040010644025"},{"key":"e_1_2_12_24_1","unstructured":"\u201cVerordnung (EU) 2019\/Des Europ\u00e4ischen Parlaments Und Des Rates Vom 11 \u201dDezember 2018 \u00dcber Tierarzneimittel Und Zur Aufhebung Der Richtlinie 2001\/82\/EG."},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8030114"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(15)00466\u20101"},{"key":"e_1_2_12_27_1","article-title":"Antimicrobial Consumption and Resistance in Bacteria From Humans and Food\u2010Producing Animals: Fourth Joint Inter\u2010Agency Report on Integrated Analysis of Antimicrobial Agent Consumption and Occurrence of Antimicrobial Resistance in Bacteria From Humans and Food\u2010Producing Animals in the EU\/EEA (JIACRA IV \u2013 2019\u20132021)","volume":"22","author":"European Centre for Disease Prevention and Control (ECDC)","year":"2024","journal-title":"EFSA Journal. European Food Safety Authority"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci7010028"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14051021"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000437"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107577"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318267"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.4.246"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2017.03.042"},{"issue":"1","key":"e_1_2_12_35_1","first-page":"59","article-title":"Antiseptics and Antibiotics as Chemotherapeutic Agents for Periodontitis Management","volume":"21","author":"Ciancio S. G.","year":"2000","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.5194\/jbji\u20106\u2010189\u20102021"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347\u2010003\u20100933\u20109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13306"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1988.4.351"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/24741264211013622"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569520903080511"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.70044"},{"key":"e_1_2_12_43_1","volume-title":"Clinical and Laboratory Standards Institute (CLSI). Methods for Determining Bactericidal Activity of Antimicrobial Agents: Approved Guideline. CLSI Document M26 A","year":"1999"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2025.1552230"},{"key":"e_1_2_12_45_1","unstructured":"R. R.Bragg \u201cTesting the Antimicrobial Activity of Treated Curtain Material When Exposed to Selected Bacterial Species With a 30 Min Contact Period \u201dBloemfontein: Dept of Microbial Biochemical & Food Biotechnology University of the Free State; 2021 Mar 23. Report No. 21PMB005."},{"key":"e_1_2_12_46_1","unstructured":"\u201cClinical and Laboratory Standards Institute (CLSI). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically: Approved Guideline \u201dCLSI Document M07 2024."},{"key":"e_1_2_12_47_1","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST) \u201cDisk Diffusion Method for Antimicrobial Susceptibility Testing \u201dVersion 13.0. V\u00e4xj\u00f6 Sweden: EUCAST; January 2025."},{"key":"e_1_2_12_48_1","unstructured":"J. F.Blaize E.Suter andC. P.Corbo \u201cSerial Dilutions and Plating: Microbial Enumeration \u201d2019."},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318264"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2013.05.007"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq212"},{"key":"e_1_2_12_52_1","first-page":"124","volume-title":"Study of the Antimicrobial Action and Disinfecting Properties of the Hypochloritic Acid Solution Obtained by the Electrolysis Method. Medicine and Biotechnologies. Series: Veterinary Sciences","author":"Brezvyn O. M.","year":"2024"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag\u20101906\u201053"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.05.018"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000639"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337140"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s438380"},{"key":"e_1_2_12_58_1","article-title":"Hypochlorous Acid as a Potential Wound Care Agent: Part I. Stabilized Hypochlorous Acid: A Component of the Inorganic Armamentarium of Innate Immunity","volume":"6","author":"Wang L.","year":"2007","journal-title":"Journal of Burns and Wounds"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.043"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/11206721221124684"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23121"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.0c02609"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.09.006"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2022\u201022468"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417444"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv474"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12528"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894\u2010020\u201000650\u20101"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.5603\/OJ.2023.0009"},{"key":"e_1_2_12_70_1","first-page":"5170","article-title":"Ocular Safety of High Doses Polyhexanide (PHMB) in Healthy Volunteers","volume":"58","author":"Papa V.","year":"2017","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13020588"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2023.11.002"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10102198"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.2217\/cpr.13.50"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057738"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S468494"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1061\/JSEDAI.0001315"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400026905"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00682\u201020"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.06.073"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195\u20106701(85)80041\u20104"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00474852"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030848"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2022.0122"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010020\u201001615\u20106"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoin.2025.100137"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.2147\/opth.S132851"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.21423\/bovine-vol50no2p180-189"},{"key":"e_1_2_12_89_1","first-page":"342","article-title":"Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency","volume":"26","author":"Sakarya S.","year":"2014","journal-title":"Wounds"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.6.671"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109394(86)90771\u20103"},{"key":"e_1_2_12_92_1","unstructured":"N.Whelan \u201cRoutes of Administration for Ocular Medications in Animals \u201dIn: MSD Veterinary Manual Veterinary Pharmacology; reviewed Oct 2021 modified Sept 2024 https:\/\/www.msdvetmanual.com\/pharmacology\/systemic\u2010pharmacotherapeutics\u2010of\u2010the\u2010eye\/routes\u2010of\u2010administration\u2010for\u2010ocular\u2010medications\u2010in\u2010animals."},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.75.5.494"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463\u20105224.2000.00093.x"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2007.00527.x"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.12.005"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12125"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367632"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420032048.ch3"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102591.2011.01911.x"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2013.03.003"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12822"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.4265\/bio.22.223"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13040309"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.3934\/microbiol.2022026"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061600"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13553"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2015\u201010766"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010022\u201002453\u20102"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy031"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102180\u20109\u2010229"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2864\u20102875.2006"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068\u2010017\u20100129\u20108"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01781\u201006"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010016\u20104700\u2010z"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj\/jim\/7000256"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3184\/003685001783238998"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492003000300005"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.6.873"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155\u20109570.1000430"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010006\u20100320\u20108"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.70141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:29:58Z","timestamp":1787380198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.70141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vop.70141"],"URL":"https:\/\/doi.org\/10.1111\/vop.70141","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70141"}}