{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:17:00Z","timestamp":1792063020376,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluation of the feasibility of argon cold plasma (ACP) use in corneal diseases in clinical practice and assessment of short\u2010 and long\u2010term safety in dogs, cats, and small mammals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Client\u2010owned animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>ACP was performed in animals with corneal diseases using the kINPenVET (Neoplas GmbH, Germany) under topical anesthesia as an adjunct to standard treatment. Early (&lt;\u200930\u2009days) and long\u2010term (&gt;\u200930\u2009days) adverse reactions and events were monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      303 eyes in 281 animals were treated with ACP (263 dogs, 8 cats, 10 small mammals) with the following conditions: spontaneous chronic corneal epithelial defects (SCCED,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009178), infected\/infiltrated ulcers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200976), keratomalacia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), corneal perforation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), other (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097). Treatment under topical anesthesia was well tolerated with only a few animals showing stress during the procedure (3.2%, 8 dogs, 1 cat). The average number of treatments per eye was 3.45\u2009\u00b1\u20091.74 with a median of 3 (1\u20139). The two direct adverse reactions observed were punctate opacities (1.3%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) and blepharospasm (0.7%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092). Short\u2010term adverse events were: epithelial tears differing from the initial ulceration (4.0%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912), development of stromal infiltrates (2.3%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), occurring\/persistent keratomalacia (2.0%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Long\u2010term follow\u2010up period averaged 173.1\u2009days with a median of 117 (30\u2013619) days. The most common long\u2010term adverse events were significant corneal fibrosis and pigmentation (4.0%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912, mostly cases of dry eyes).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ACP with kINPenVET is a clinically feasible outpatient treatment for various corneal diseases with a low number of short\u2010 and long\u2010term adverse reactions and events. It can be easily integrated into clinical treatment protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70145","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:34:38Z","timestamp":1769765678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility and Safety of Argon Cold Plasma Use as an Adjunctive Treatment for Corneal Disease in Dogs, Cats and Small Mammals: A Prospective Clinical Study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6125-8580","authenticated-orcid":false,"given":"Petr","family":"Soukup","sequence":"first","affiliation":[{"name":"Animal Eye Practice  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-4213","authenticated-orcid":false,"given":"Ingrid","family":"Allgoewer","sequence":"additional","affiliation":[{"name":"Animal 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D.Roberts J.Salmon J.Thomas andK.Stapelmann \u201cAssessment of Ocular Toxicity Following Corneal Application of Cold Atmospheric Plasma in Rabbits Using Multimodal Imaging \u201dIn IEOC Conference Lucerne (2025)."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010140\u201010\u2010200405180\u201000009"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12838"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13269"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.2031"},{"issue":"10","key":"e_1_2_10_28_1","first-page":"2262","article-title":"Morphology and Immunohistochemistry of Spontaneous Chronic Corneal Epithelial Defects (SCCED) in Dogs","volume":"42","author":"Bentley E.","year":"2001","journal-title":"Investigative Ophthalmology and Visual 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