{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:14:21Z","timestamp":1787508861767,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the prevalence, clinical presentation, and histopathological features of primary glaucoma (PG) in a French population of domestic rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Client\u2010owned rabbits, presented to the Ophthalmology Unit of Alfort from January 2017 to December 2024, were diagnosed with glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>A retrospective review of medical records was performed. Rabbits were included if they presented signs of ocular hypertension associated with an IOP exceeding 20\u2009mmHg. Cases with signs of secondary glaucoma were excluded. Ophthalmic examination findings, gonioscopy (when available), treatment, outcomes, and histopathological results (of enucleated eyes) were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 211 rabbits examined for ocular disease, 35 were diagnosed with glaucoma (16.6%). Primary glaucoma was suspected in 4 rabbits (8 eyes), representing 11.4% of glaucomatous rabbits and 19.5% of affected eyes. Affected rabbits had bilateral glaucoma and belonged to various breeds (giant, lop, and dwarf rabbits). Clinical signs included buphthalmos, corneal edema, and mydriasis; IOP ranged from 23 to 65\u2009mmHg. Gonioscopy, performed in 3 eyes, revealed collapsed iridocorneal angles. Topical antiglaucoma treatment and diode laser cyclophotocoagulation were largely ineffective. Histopathological analysis of three eyes showed features consistent with anterior segment dysgenesis in one rabbit and inconclusive findings without secondary causes of glaucoma in the other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Primary glaucoma may be more prevalent in pet rabbits than previously recognized. Despite treatment, long\u2010term control of IOP and preservation of vision remain challenging. Early detection is essential, and further prospective studies are warranted to better characterize the disease and optimize management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70147","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:19:12Z","timestamp":1771463952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suspected Primary Glaucoma in a French Population of Pet Rabbits: A Retrospective Study (2017\u20132024) of 4 Cases (8 Eyes)"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4669-8472","authenticated-orcid":false,"given":"Jessica","family":"Damst\u00e9n","sequence":"first","affiliation":[{"name":"Department of Veterinary Ophthalmology Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, CHUV\u2010AC  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-1844","authenticated-orcid":false,"given":"Matthieu","family":"Bott","sequence":"additional","affiliation":[{"name":"Department of Veterinary Ophthalmology Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, CHUV\u2010AC  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-0281","authenticated-orcid":false,"given":"Coline","family":"Jondeau","sequence":"additional","affiliation":[{"name":"Department of Veterinary Ophthalmology Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, CHUV\u2010AC  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-9746","authenticated-orcid":false,"given":"Patricia","family":"Muffat\u2010es\u2010Jacques","sequence":"additional","affiliation":[{"name":"CHUV\u2010AC, Exotic Medicine Service Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1819-6239","authenticated-orcid":false,"given":"Valentine","family":"Muller","sequence":"additional","affiliation":[{"name":"Histology and Pathology Unit Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0188-2554","authenticated-orcid":false,"given":"Gr\u00e9gory","family":"Jouvion","sequence":"additional","affiliation":[{"name":"Histology and Pathology Unit Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"},{"name":"Laboratoire de Sant\u00e9 Animale, VIROLOGIE Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, Anses, INRAE  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-6930","authenticated-orcid":false,"given":"Edouard","family":"Reyes\u2010Gomez","sequence":"additional","affiliation":[{"name":"Histology and Pathology Unit Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"},{"name":"INSERM, U955 IRMB Univ Paris\u2010Est Cr\u00e9teil  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-3482","authenticated-orcid":false,"given":"Gillian C.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine, Department of Pathobiological Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-5515","authenticated-orcid":false,"given":"Sabine","family":"Chahory","sequence":"additional","affiliation":[{"name":"Department of Veterinary Ophthalmology Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, CHUV\u2010AC  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1173","volume-title":"Veterinary Ophthalmology: Two Volume Set","author":"Plummer C. E.","year":"2021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12660"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367782780891679"},{"key":"e_1_2_12_5_1","first-page":"2109","volume-title":"Veterinary Ophthalmology: Two Volume Set","author":"Eaton S.","year":"2021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2020.03.009"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050293"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2011.00879.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12981"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13148"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/tjo.TJO\u2010D\u201023\u201000070"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12843"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463\u20105216.2001.00178.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42490\u2010020\u201000045\u20101"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001215"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.70147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:57:04Z","timestamp":1774843024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.70147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/vop.70147"],"URL":"https:\/\/doi.org\/10.1111\/vop.70147","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70147"}}