{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:28:14Z","timestamp":1774848494249,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Conjunctival lymphoma is rare in dogs, with most cases exhibiting the B cell phenotype. Concurrent cutaneous and conjunctival T cell involvement is exceptionally uncommon. This case report describes a dog with cutaneous T\u2010cell lymphoma that presented with chronic conjunctivitis and conjunctival T\u2010lymphocyte infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animal Studied<\/jats:title>\n                    <jats:p>A 15\u2010year\u2010old spayed female Chihuahua presented with a 3\u2010month history of bilateral conjunctivitis that was unresponsive to conventional therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures and Results<\/jats:title>\n                    <jats:p>Physical examination revealed severe conjunctival inflammation extending into the corneal limbus and perinasal depigmentation. Conjunctival cytology revealed the presence of mixed inflammatory cells. Histopathological examination of the nasal skin confirmed an epitheliotropic T\u2010cell lymphoma with dense atypical lymphoid infiltration. Immunohistochemistry revealed CD3\u2010positive, CD79\u03b1\u2010negative cells. Conjunctival biopsy demonstrated lymphocytic infiltration with a similar immunophenotype, although cellular atypia was minimal and mitotic figures were rare. The patient was initially managed with topical corticosteroids, followed by oral prednisolone, and the patient survived for 191\u2009days post\u2010diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>This case underscores the need to consider neoplastic disease in dogs presenting with chronic conjunctivitis, particularly when mucocutaneous lesions are also present. The identification of T\u2010lymphocyte\u2010predominant conjunctival infiltration in a dog with confirmed cutaneous T\u2010cell lymphoma suggests either an early stage of neoplastic involvement or a reactive inflammatory process. These findings emphasize the value of careful diagnostic evaluation, including tissue biopsy and immunohistochemistry, when managing refractory ocular inflammatory conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70167","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:28:43Z","timestamp":1772983723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous T\u2010Cell Lymphoma With Conjunctival T\u2010Lymphocyte Infiltration in a Dog"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5212-3221","authenticated-orcid":false,"given":"Takuya","family":"Yogo","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Surgery, School of Veterinary Medicine Nippon Veterinary and Life Science University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Momota","sequence":"additional","affiliation":[{"name":"Department of Veterinary Nursing, School of Veterinary Nursing and Techology Nippon Veterinary and Life Science University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Applied Science, School of Veterinary Nursing and Technology Nippon Veterinary and Life Science University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Applied Science, School of Veterinary Nursing and Technology Nippon Veterinary and Life Science University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105829.2008.00176.x"},{"key":"e_1_2_11_3_1","first-page":"421","article-title":"Canine Cutaneous Epitheliotropic Lymphoma (Mycosis Fungoides) is a Proliferative Disorder of CD8+ T Cells","volume":"144","author":"Moore P. 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