{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:10:52Z","timestamp":1778659852390,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Therapeutic success in canine corneal ulcers depends on appropriate antimicrobial selection and reliable at\u2010home drug delivery. However, veterinary data on owner adherence remain limited and are largely self\u2010reported. Evidence from human ophthalmology indicates that dosing frequency, follow\u2010up interval, and hands\u2010on technique training strongly influence treatment outcomes. This viewpoint advocates a shift from drug\u2010centered to delivery\u2010centered management and proposes a testable four\u2010part Clinical Adherence Bundle (CAB\u20104): scheduling timely rechecks within 14\u2009days, minimizing dosing frequency when microbiologically appropriate, providing standardized staff\u2010led technique education with written or video materials, and anticipating medication needs to prevent stockouts. Each component is designed to be measurable in routine practice, auditable within clinical workflows, and scalable across both referral and primary\u2010care settings. Finally, we propose a pragmatic research framework to prospectively evaluate the CAB\u20104 by linking adherence metrics with objective clinical outcomes, including epithelial healing time and corneal perforation.<\/jats:p>","DOI":"10.1111\/vop.70175","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T02:38:26Z","timestamp":1775270306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Drug Choice to Drug Delivery: A Viewpoint on Measuring and Improving Owner Adherence in Canine Corneal Ulcers"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5212-3221","authenticated-orcid":false,"given":"Takuya","family":"Yogo","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Surgery, School of Veterinary Medicine Nippon Veterinary and Life Science University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.197"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1998.56"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301\u20104738.73693"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792\u2010010\u20109362\u20103"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl\u20102011\u2010000748"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.25.03.0132"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.70039"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0161\u20106420(83)34583\u20108"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000002166"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34167"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo\u20102023\u2010324488"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201066296\u20103"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnsa.2022.100079"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.70175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:35:03Z","timestamp":1778657703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.70175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/vop.70175"],"URL":"https:\/\/doi.org\/10.1111\/vop.70175","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70175"}}