{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:04:14Z","timestamp":1782547454544,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["1919B012403270"],"award-info":[{"award-number":["1919B012403270"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of ivermectin administration on aqueous tear production and ocular surface health in dogs and to investigate its potential association with quantitative keratoconjunctivitis sicca (KCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 128 mixed\u2010breed dogs were included: 64 ivermectin\u2010treated and 64 untreated controls. Lacrimal secretion and ocular surface status were assessed using Schirmer tear test I (STT\u2010I), fluorescein staining, and corneal opacity scoring. Data were analyzed with nonparametric tests, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 36\u2009h after treatment, STT\u2010I values were significantly reduced from baseline in the ivermectin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas no significant change was observed in controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Reduction in aqueous tear production (\u0394STT\u2010I) was greater in ivermectin\u2010treated dogs (\u22124.38\u2009\u00b1\u20092.7\u2009mm\/min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than in controls (\u22120.14\u2009\u00b1\u20090.9\u2009mm\/min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Mean STT\u2010I at 36\u2009h was lower in the treated group (6.05\u2009\u00b1\u20093.5\u2009mm\/min) compared with controls (10.08\u2009\u00b1\u20093.2\u2009mm\/min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Fluorescein uptake was observed more frequently in ivermectin\u2010treated dogs (32.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) than in controls (7.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). KCS severity scores were significantly higher in the ivermectin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while the control median score was 1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Routine systemic ivermectin treatment was associated with reduced aqueous tear production. The mechanism was not evaluated but may involve altered neural control of lacrimal secretion. Even at recommended doses, ivermectin may predispose susceptible dogs to subclinical dry eye; therefore, quantitative tear testing is advisable in dogs receiving ivermectin prophylaxis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70180","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T03:19:41Z","timestamp":1775877581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic Ivermectin Administration Reduces Aqueous Tear Production and Affects Ocular Surface Health in Clinically Healthy Dogs"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-7782","authenticated-orcid":false,"given":"Yakup","family":"Kocaman","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Yozgat Bozok University  Yozgat Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latif Emrah","family":"Yanmaz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","article-title":"Ivermectin: A Multifaceted Drug With a Potential Beyond Anti\u2010Parasitic Therapy","volume":"16","author":"Kaur B.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800399167"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-29007-7.00053-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200111000-00012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006663"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2012.00060"},{"key":"e_1_2_11_8_1","volume-title":"Adler's Physiology of the Eye","author":"Dartt D. 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