{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:11:06Z","timestamp":1778659866214,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy of a newly developed adhesive tissue sealant, gelatinized cornea\u2010derived decellularized extracellular matrix (Cod\u2010ECM) for the treatment of stromal ulcers in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animal Studied<\/jats:title>\n                    <jats:p>This study included 60 eyes of 56 dogs diagnosed with stromal ulcerative keratitis, limited to corneal ulcers involving less than 50% of corneal thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>Thirty eyes were treated with gelatinized Cod\u2010ECM in combination with standard medical therapy, while the remaining eyes received conventional therapy alone. Assessments included the corneal opacity score (assessed using the semi\u2010quantitative preclinical ocular toxicology scoring system), degree of corneal neovascularization, and time taken for complete epithelialization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Complete re\u2010epithelialization was achieved in both the gelatinized Cod\u2010ECM group and the Control group. The gelatinized Cod\u2010ECM group exhibited a significant improvement in corneal opacity compared with that in the Control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Complete epithelialization occurred significantly faster in the GelCODE group (3.9\u2009\u00b1\u20090.7\u2009days) than in the Control group (5.3\u2009\u00b1\u20091.0\u2009days) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The use of gelatinized Cod\u2010ECM was not associated with a significant improvement in corneal vascularization compared to the Control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gelatinized Cod\u2010ECM is a simple, non\u2010invasive, and cost\u2010effective treatment option for stromal corneal ulcers. Compared to conventional therapy, it provides superior corneal clarity and significantly accelerates epithelial healing. Although it showed no significant effect on corneal neovascularization, its ease of application and therapeutic benefits make it a promising and widely applicable approach for the management of stromal corneal ulcers in veterinary practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70181","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:27:15Z","timestamp":1776068835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Non\u2010Invasive Treatment for Canine Corneal Ulcers: Application of New Extracellular Matrix\u2010Based Sticky Sealants"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9713-536X","authenticated-orcid":false,"given":"Su\u2010Jung","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Veterinary Ophthalmology, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-2921","authenticated-orcid":false,"given":"Je\u2010Hwan","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Ophthalmology, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Young","family":"Park","sequence":"additional","affiliation":[{"name":"Biobricks Co., Ltd.  Kyungbuk Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-3495","authenticated-orcid":false,"given":"Jinah","family":"Jang","sequence":"additional","affiliation":[{"name":"Biobricks Co., Ltd.  Kyungbuk Republic of Korea"},{"name":"Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH)  Kyungbuk Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-6269","authenticated-orcid":false,"given":"Joon\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Ophthalmology, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"652","article-title":"Veterinary Ophthalmology (6th Edition)","volume":"259","author":"Carter R. 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