{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:10:55Z","timestamp":1778659855002,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002583","name":"Gyeongsang National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical outcome of intravitreal cidofovir injection for palliative management of refractory end\u2010stage glaucoma and vision loss in silicone oil\u2010filled eyes following retinal reattachment surgery in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>Medical records of dogs that underwent a single intravitreal cidofovir injection for pharmacologic ciliary body ablation were retrospectively reviewed. Data collected included clinical history, intraocular pressure (IOP), post\u2010injection ocular comfort, complications, and follow\u2010up duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four dogs (four eyes) were included. All treated eyes demonstrated a marked reduction in IOP at the first post\u2010injection recheck (14\u201328\u2009days after injection; post\u2010injection IOP range: 3\u20137\u2009mmHg). Adequate pain control was achieved in all dogs throughout the follow\u2010up period (median follow\u2010up: 306.5\u2009days; range: 40\u2013369\u2009days). Progressive phthisis bulbi developed in one case at long\u2010term follow\u2010up, while the remaining eyes maintained acceptable globe integrity and cosmetic appearance. Moderate to severe post\u2010injection ocular discharge, conjunctival hyperemia, and aqueous flare were observed in all cases and were manageable with routine topical therapy. All owners reported satisfaction with post\u2010injection comfort and appearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single intravitreal cidofovir injection may represent a feasible palliative option for controlling intraocular pressure and ocular pain in silicone oil\u2010filled eyes with refractory glaucoma when enucleation is declined. Further studies are needed to better characterize long\u2010term safety and outcomes in this clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70185","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:15:05Z","timestamp":1777349705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravitreal Cidofovir Injection for Refractory End\u2010Stage Glaucoma and Vision Loss in Silicone Oil\u2010Filled Eyes Following Retinal Reattachment Surgery in Dogs: Four Cases"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-8656","authenticated-orcid":false,"given":"Sunhyo","family":"Kim","sequence":"first","affiliation":[{"name":"Ilsan Animal Medical Center  Goyang\u2010si Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-8950","authenticated-orcid":false,"given":"Jaeho","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Ophthalmology, College of Veterinary Medicine Gyeongsang National University  Jinju\u2010si Gyeongsangnam\u2010do Republic of Korea"},{"name":"Institute of Animal Medicine, College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1173","volume-title":"Veterinary Ophthalmology","author":"Plummer C. E.","year":"2021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12816"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12071"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.24.03.0199"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.17555\/jvc.2017.10.34.5.341"},{"key":"e_1_2_12_7_1","first-page":"1575","volume-title":"Veterinary Ophthalmology","author":"Hoffman A. R.","year":"2021"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04049.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01009.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12246"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12912"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2024.09.006"},{"key":"e_1_2_12_13_1","article-title":"Intraocular Drug Delivery Into Silicone Oil\u2010Filled Eyes: Experience With Cidofovir (HPMPC)","volume":"37","author":"Rahhal F. M.","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S483325"},{"key":"e_1_2_12_15_1","article-title":"Distribution of Triamcinolone Acetonide After Intravitreal Injection Into Silicone Oil\u2010Filled Eye","volume":"2016","author":"Ma D.","year":"2016","journal-title":"BioMed Research International"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.70185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:34:49Z","timestamp":1778657689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.70185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/vop.70185"],"URL":"https:\/\/doi.org\/10.1111\/vop.70185","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"2026-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70185"}}