{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:22:55Z","timestamp":1783441375933,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Justification<\/jats:title>\n Circadian variations in central corneal thickness (CCT) and their correlation with intraocular pressure (IOP) have not been reported in horses. This information may be clinically relevant when interpreting IOP readings.<\/jats:p>\n <\/jats:sec>\n \n Procedures<\/jats:title>\n Twenty\u2010four eyes of 6 healthy adult gelded males and 6 healthy adult intact mares were evaluated. Rebound tonometry (TonoVet, Jorgensen Laboratories) followed by ultrasonic pachymetry (iPac Pachymeter, Reichert technologies) was performed in both eyes every 3\u2009h over 24\u2009h during the natural 14\u2010h daylight summer photoperiod.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Central corneal thickness varied significantly over time (\n F<\/jats:italic>\n \u2009=\u20095.296, df\u2009=\u20098, 184,\n p<\/jats:italic>\n \u2009<\u20090.0001), being significantly greater during the dark phase compared with the light phase (mean difference\u2009=\u20094.47\u2009\u03bcm, 95% CI: 2.11 to 6.84;\n p<\/jats:italic>\n \u2009=\u20090.0003). Intraocular pressure varied significantly over time (\n F<\/jats:italic>\n \u2009=\u20092.886, df\u2009=\u20098, 184,\n p<\/jats:italic>\n \u2009=\u20090.0047). The largest difference was observed between 0\u2009h (7\u2009a.m.) and 15\u2009h (10\u2009p.m.), with IOP being higher at 15\u2009h by 3.96\u2009mmHg (95% CI: 0.90 to 7.01). There was no significant correlation between CCT and IOP at any time point (\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.044\u2009mmHg per \u03bcm increase in CCT, 95% CI: \u22120.100 to 0.013;\n p<\/jats:italic>\n \u2009=\u20090.14).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In healthy horses,\n CCT<\/jats:styled-content>\n showed minimal circadian variation that was statistically significant but not clinically relevant and was not associated with intraocular pressure. Intraocular pressure exhibited a modest diurnal rhythm, peaking at the end of the light phase, supporting species\u2010specific differences in circadian ocular physiology.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vop.70194","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:44:25Z","timestamp":1779252265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Circadian Variations of Central Corneal Thickness and Its Correlation With Intraocular Pressures in Healthy Horses"],"prefix":"10.1111","volume":"29","author":[{"given":"Carolina","family":"Iturregui","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-8313","authenticated-orcid":false,"given":"Chin\u2010Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-9063","authenticated-orcid":false,"given":"Renee T.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-6941","authenticated-orcid":false,"given":"Pilar","family":"Camacho\u2010Luna","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"102","article-title":"Diurnal Variation of Corneal Thickness in the Cat","volume":"26","author":"Chan\u2010Ling T.","year":"1985","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"10","key":"e_1_2_10_3_1","first-page":"775","article-title":"The Circadian Rhythm of the Intraocular Pressure in the New Zealand White Rabbit","volume":"14","author":"Katz R. 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