{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:23:32Z","timestamp":1783441412775,"version":"3.54.6"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006515","name":"El\u00e4inl\u00e4\u00e4ketieteen Tutkimuksen Tukis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the short\u2010term ophthalmic effects of vatinoxan, a peripherally selective alpha2\u2010adrenoceptor antagonist, in detomidine\u2010sedated horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Seven healthy horses without ophthalmic disease in a randomized, masked, two\u2010period crossover study design, with a \u2265\u20097\u2010day rest period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>\n                      After a bilateral palpebral block (lidocaine 40\u2009mg) and baseline data collection, horses received intravenous detomidine (20\u2009\u03bcg\/kg [DET]) or DET with vatinoxan (200\u2009\u03bcg\/kg [DET\u2010VAT]). Intraocular pressure (IOP) was measured from the left eye while tear production (Schirmer tear test \u22121; STT) and vertical pupil diameter (VPD) were measured from the right eye at pre\u2010determined intervals until 25\u2009min post\u2010treatment. Comparisons within and between treatments were analyzed with Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests (for IOP and VPD) or Wilcoxon's Rank Sum tests (for STT) followed by the Holm\u2010Bonferroni\n                      <jats:italic>post hoc<\/jats:italic>\n                      adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall post\u2010treatment IOP across time points was lower after DET (15.7\u2009\u00b1\u20091.9 [mean\u2009\u00b1\u2009standard deviation] mmHg) than DET\u2010VAT (16.9\u2009\u00b1\u20092.0\u2009mmHg) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). IOP remained significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) lower than baseline after DET for the whole 25\u2009min observational period, while for DET\u2010VAT the corrected pairwise comparisons to baseline did not reach significance. The median (range) STT increased from baseline 17 (13\u201325) mm\/min to 24 (18\u201335) mm\/min (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) at 25\u2009min after DET and from 18 (11\u201335) mm\/min to 30 (18\u201335) mm\/min (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) after DET\u2010VAT, respectively. VPD did not differ significantly from baseline after either treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vatinoxan alleviated detomidine\u2010associated early decrease in IOP in healthy horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70206","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:25:31Z","timestamp":1780482331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Early Ophthalmic Effects of Vatinoxan in Healthy Detomidine\u2010Sedated Horses"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-1660","authenticated-orcid":false,"given":"Minna Pauliina","family":"Mustikka","sequence":"first","affiliation":[{"name":"Department of Equine and Small Animal Medicine, 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