{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:34:41Z","timestamp":1792542881079,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the practicability and diagnostic value of anterior segment optical coherence tomography (AS\u2010OCT) in cats, focusing on image quality and distinguishing iris melanosis from iris melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010six client\u2010owned cats were examined using a ZEISS Primus 200 OCT system. Image acquisition occurred without anesthesia in 65 cats; eight required injectable sedation, and three received anxiolytic medication. Mean iris thickness was measured; pigmentation\u2010to\u2010normal (PN) ratios were calculated from paired comparisons. OCT\u2010based structural characteristics were analyzed in 49 eyes with suspected melanosis and 27 with suspected melanoma. Histological confirmation was available in 15 melanoma cases and one melanosis case following enucleation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In normal and suspected melanosis\u2010affected irides, mean iris thickness was similar (316.32\u2009\u00b1\u200989.36\u2009\u03bcm; 319.20\u2009\u00b1\u200978.75\u2009\u03bcm; PN\u2009\u22481.07\u2009\u00b1\u20090.14), with preserved architecture and consistent OCT layer visibility. In suspected and confirmed melanomas, mean iris thickness increased significantly (474.25\u2009\u00b1\u2009139.14\u2009\u03bcm; PN\u2009\u22481.61\u2009\u00b1\u20090.52; 592.54\u2009\u00b1\u2009186.89\u2009\u03bcm; PN\u2009\u22481.58\u2009\u00b1\u20090.27), accompanied by posterior signal attenuation and loss of structural detail. All 15 histologically confirmed melanomas matched the OCT\u2010based suspicion, yielding a diagnostic sensitivity of 100%. One case initially classified as suspected melanosis underwent enucleation due to clinical progression and was histopathologically confirmed as benign melanosis, supporting the accuracy of the OCT\u2010based assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AS\u2010OCT is a valuable, non\u2010invasive modality for in\u00a0vivo assessment of the feline iris. It is a feasible and practical tool that may support diagnosis of iris melanoma and assist in clinical decision\u2010making, particularly regarding the need for enucleation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70224","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:38:52Z","timestamp":1783323532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Practicability and Effectiveness of Anterior Segment Optical Coherence Tomography (\n                    <scp>AS<\/scp>\n                    \u2010\n                    <scp>OCT<\/scp>\n                    ) of the Feline Iris as a Potential Biomarker for Iris Melanoma: A Study of 76 Cases"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2688-6420","authenticated-orcid":false,"given":"Natalie","family":"Lanzend\u00f6rfer","sequence":"first","affiliation":[{"name":"Veterinary Ophthalmology Clinic Dres. Hoffmann and Thal  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0563-7737","authenticated-orcid":false,"given":"Carolina","family":"Naranjo Freixa","sequence":"additional","affiliation":[{"name":"IDEXX Laboratorios  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Veterinary Ophthalmology Clinic Dres. Hoffmann and Thal  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Stieger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Justus\u2010Liebig\u2010University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia A.","family":"Deeg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Chair of Physiology Ludwig\u2010Maximilians\u2010University of Munich  Planegg\u2010Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.17555\/jvc.2016.08.33.4.225"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.61262\/vetjku.1303039"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci9020046"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12344"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00006.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8120225"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.23.07.0387"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12718"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00066.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18762017"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci11060261"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01045.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304481"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59122114"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5301\/EJO.2011.6214"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.66742"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00532.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-182"},{"key":"e_1_2_12_20_1","doi-asserted-by":"crossref","unstructured":"Y.Zhu T.Tan andY.Wang \u201cBiometric Personal Identification Based on Iris Patterns \u201dProceedings of the 15th International Conference on Pattern Recognition Barcelona Spain. 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