{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:09:11Z","timestamp":1788944951590,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019354","name":"Azabu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019354","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the effects of 0.002% omidenepag isopropyl (OMDI) ophthalmic solution on intraocular pressure (IOP) and pupil diameter (PD) in clinically normal dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five healthy dogs (10 eyes) were included in this prospective randomized, observer\u2010masked, placebo\u2010controlled study. An initial pilot study was conducted to evaluate IOP and ocular irritation up to 48\u2009h after a single instillation of OMDI. For the subsequent main study, each dog received one drop of 0.002% OMDI in one randomly selected eye and placebo in the contralateral eye once daily. IOP, PD, and conjunctival hyperemia scores were measured five times daily during the baseline (3\u2009days), treatment (5\u2009days), and recovery (3\u2009days) periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A single instillation of topical OMDI significantly lowered IOP by a maximal IOP reduction of 7.2\u2009mmHg (60%). In the repeated\u2010dose study, once\u2010daily administration of topical OMDI significantly reduced average daily IOP\u2009\u00b1\u2009SD by 4.8\u2009\u00b1\u20090.68\u2009mmHg (38.6%) and 6.1\u2009\u00b1\u20090.75\u2009mmHg (44.3%), relative to baseline and contralateral controls, respectively. No clinically relevant miosis was observed in OMDI\u2010treated eyes. Adverse events were limited to mild\u2010to\u2010moderate conjunctival hyperemia in OMDI\u2010treated eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Once\u2010daily administration of 0.002% OMDI resulted in a robust reduction in IOP without inducing miosis and was well\u2010tolerated in normal dogs. Further studies are warranted to assess its therapeutic potential and long\u2010term safety in dogs with glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70239","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:24:14Z","timestamp":1785842654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Topical Omidenepag Isopropyl on Intraocular Pressure and Pupil Diameter in Normal Dogs"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5126-4771","authenticated-orcid":false,"given":"Hikaru","family":"Tsujimura","sequence":"first","affiliation":[{"name":"Laboratory of Small Animal Clinics, School of Veterinary Medicine Azabu University  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Kameda","sequence":"additional","affiliation":[{"name":"Laboratory of 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