{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:09:13Z","timestamp":1788944953563,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009944","name":"American College of Veterinary Ophthalmologists Vision for Animals Foundation","doi-asserted-by":"publisher","award":["VAF2016\u201001"],"award-info":[{"award-number":["VAF2016\u201001"]}],"id":[{"id":"10.13039\/100009944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine longitudinal changes in chromatic pupillary light reflexes (cPLR) and retinal layers in dogs with sudden acquired retinal degeneration syndrome (SARDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Clinical evaluation: Fifteen SARDS\u2010affected and nine control dogs. Histology: Achieved globes from five SARDS\u2010affected (1\u20137\u2009years post\u2010diagnosis) and eight age\u2010matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>Dogs underwent ophthalmic examination and electroretinography to confirm SARDS. Chromatic pupillometry and Fourier\u2010domain optical coherence tomography (FD\u2010OCT) were performed at baseline (once for control; &lt;\u20091\u2010month post\u2010blindness for SARDS\u2010affected dogs), and follow\u2010up (3, 6 and 12\u2009months post\u2010diagnosis). The extent, velocity and latency of pupil constriction were evaluated. Retinal thickness was measured from the FD\u2010OCT images. Ganglion cell counts were determined from histologic sections stained with hematoxylin and eosin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, SARDS\u2010affected dogs showed significantly reduced extent and velocity of red light PLR, and reduced extent with prolonged latency of white light PLR, relative to controls; white light velocity and all blue light parameters did not differ. White light PLR velocity significantly decreased over time in SARDS\u2010affected dogs. FD\u2010OCT in SARDS\u2010affected dogs revealed progressive total retinal thinning but stable inner retinal thickness. Histology of SARDS\u2010affected eyes identified diffuse outer retinal atrophy with relative inner retinal preservation; ganglion cell counts were not different between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chromatic pupillometry reflects the selective preservation of melanopsin\u2010containing retinal ganglion cell function despite progressive photoreceptor degeneration in SARDS. The combined longitudinal use of chromatic pupillometry and FD\u2010OCT provides a comprehensive assessment of the evolving functional and structural changes in SARDS\u2010affected dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70248","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:16:19Z","timestamp":1787037379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Evaluation of Chromatic Pupillometry and Retinal Thickness in Dogs With Sudden Acquired Retinal Degeneration Syndrome"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-1062","authenticated-orcid":false,"given":"Soohyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-4335","authenticated-orcid":false,"given":"David J.","family":"Maggs","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana D.","family":"Marangakis","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Motta","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-9677","authenticated-orcid":false,"given":"Sara M.","family":"Thomasy","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis  Davis California USA"},{"name":"Department of Ophthalmology &amp; Vision Science, School of Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12291"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12504"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5326\/0450207"},{"key":"e_1_2_11_5_1","unstructured":"S. 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