{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:09:10Z","timestamp":1788944950410,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the accuracy of the TONOVET Plus (TVP) and TONOVET Pro (TVPR) in measuring intraocular pressure (IOP) in ex\u00a0vivo cynomolgus monkey eyes compared to manometry, and to determine the accuracy of Canine and Lapine calibration modes:<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Five enucleated eyes from three cynomolgus monkeys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>The anterior chambers were cannulated to regulate IOP manometrically from 5 to 80\u2009mmHg. Agreement between tonometric and manometric readings was analyzed using a linear mixed\u2010effects model (LMM), Lin's concordance correlation coefficient (CCC), and repeated\u2010measures Bland\u2013Altman analysis. Data points at the 80\u2009mmHg manometric setting were excluded to prevent artificial distortion from the devices' maximum display limits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Strong linear relationships were observed between manometric and tonometric IOPs for all modes. However, the Lapine mode demonstrated proportional overestimation with steeper regression slopes compared to the Canine mode. The Canine mode showed excellent agreement (CCC: 0.967 for TVP, 0.971 for TVPR) with minimal mean bias. In contrast, the Lapine mode exhibited significant positive bias and wider limits of agreement, particularly at higher pressures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both TVP and TVPR provided accurate and reliable IOP measurements in cynomolgus monkeys when using the Canine calibration mode. Despite the central corneal thickness of cynomolgus monkeys being closer to that of rabbits, the Lapine mode resulted in significant overestimation and is not recommended. Among the tested settings, the Canine mode provided highly accurate IOP measurements with minimal bias, whereas the Lapine mode significantly overestimated IOP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70265","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:10:23Z","timestamp":1788844223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ex Vivo Validation of the\n                    <scp>TONOVET<\/scp>\n                    Plus and\n                    <scp>TONOVET<\/scp>\n                    Pro in Cynomolgus Monkeys (\n                    <i>Macaca fascicularis<\/i>\n                    ): Comparison of Canine and Lapine Calibration Modes"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8474-576X","authenticated-orcid":false,"given":"Wontae","family":"Kim","sequence":"first","affiliation":[{"name":"KeyPrime Research  Cheongju\u2010si Chungcheongbuk\u2010do Korea"},{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-0891","authenticated-orcid":false,"given":"Seonmi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8589-1305","authenticated-orcid":false,"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Eyes &amp; Teeth Animal Clinic  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-165X","authenticated-orcid":false,"given":"Jun Young","family":"Lee","sequence":"additional","affiliation":[{"name":"KeyPrime Research  Cheongju\u2010si Chungcheongbuk\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-7116","authenticated-orcid":false,"given":"Kangmoon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Veterinary Ophthalmology","author":"Gelatt K. 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