{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:08:39Z","timestamp":1789704519295,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n To report the first documented case of corneal sequestration and distichiasis in a binturong (\n \n Arctictis binturong<\/jats:italic>\n <\/jats:styled-content>\n ), discuss implications of disease prevalence in a non\u2010domestic feliform, and hypothesize on potential etiology and predisposing factors for corneal sequestration.\n <\/jats:p>\n <\/jats:sec>\n \n Animal Studied<\/jats:title>\n A 15\u2010year\u2010old intact male binturong.<\/jats:p>\n <\/jats:sec>\n \n Procedures<\/jats:title>\n Anesthetized physical examination and ophthalmic assessment were performed by board\u2010certified specialists. Corneal cytology, culture and sensitivity, debridement of the sequestra in lieu of keratectomy, histopathology, and cryoepilation were performed, followed by 4\u2009weeks of topical therapy. The patient was euthanized 3\u2009years later for unrelated reasons, and a necropsy was performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Examination found bilateral distichiasis. In the left cornea, two brown, ovoid lesions flanked an area of yellow infiltrate, all overlying a raised, ulcerated granulation bed. Corneal cytology identified neutrophils, cocci, and rare rods. Histopathology of the debrided tissue showed coagulative to lytic necrosis with intralesional gram\u2010positive cocci, indicating sequestration and secondary infection. Aerobic culture yielded\n \n Staphylococcus delphini<\/jats:italic>\n <\/jats:styled-content>\n and\n \n Streptococcus acidominimus<\/jats:italic>\n <\/jats:styled-content>\n . Photo updates 4\u2009weeks post\u2010operation showed resolution of clinical signs. Later, necropsy and histology showed chronic ocular changes without recurrence of sequestra.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Clinical and histopathologic findings identified corneal sequestration, with chronic irritation secondary to distichiasis as a suspected factor. Surgical debridement and cryoepilation achieved long\u2010term clinical resolution, with only mild distichiae regrowth and no sequestration recurrence after 3\u2009years. Corneal sequestration is thought to predominantly affect domestic cats (\n \n Felis catus<\/jats:italic>\n <\/jats:styled-content>\n ); this report expands the clinical relevance of corneal sequestration to an exotic species and supports chronic corneal irritation as a predisposing factor.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vop.70267","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:29:10Z","timestamp":1789702150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Corneal Sequestration and Bilateral Distichiasis in<\/scp>\n a\n Binturong<\/scp>\n (\n Arctictis binturong<\/i>\n )"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7350-9142","authenticated-orcid":false,"given":"Vienna","family":"Lunking","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-5791","authenticated-orcid":false,"given":"Mandy","family":"Womble","sequence":"additional","affiliation":[{"name":"Population Health and Pathobiology North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-1245","authenticated-orcid":false,"given":"Hannah L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-8795","authenticated-orcid":false,"given":"Sarah","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-5936","authenticated-orcid":false,"given":"Tara","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6198-2170","authenticated-orcid":false,"given":"Elizabeth","family":"Rose","sequence":"additional","affiliation":[{"name":"Population Health and Pathobiology North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-7491","authenticated-orcid":false,"given":"Annie","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1748-5827.1988.tb03515.x","article-title":"Corneal Necrosis and Sequestration in the Cat: A Review and Record of 100 Cases","volume":"29","author":"Startup F. 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