{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:52:43Z","timestamp":1791017563021,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 7\u2010month\u2010old intact female mixed\u2010breed dog presented emergently for inability to walk, lethargy, and vomiting. The patient was diagnosed with immune\u2010mediated polyarthritis (IMPA) and secondary systemic inflammatory response syndrome (SIRS). Bilateral keratouveitis and secondary glaucoma developed within 24\u2009h of presentation. Thorough diagnostic testing failed to identify an underlying etiology. Despite aggressive medical management, the patient developed rapid vision loss. Due to poor visual prognosis and anticipated need for long\u2010term medical management, both eyes were enucleated. Histopathological evaluation of both globes revealed severe corneal endothelial injury most consistent with endotheliitis with associated uveitis and endophthalmitis. Testing of ocular tissue with PCR and immunohistochemistry for canine adenovirus was negative, and comprehensive infectious disease screening, joint cultures, and ocular histopathology identified no other causative agents. Following enucleation, the dog systemically improved with anti\u2010inflammatory and antimicrobial medical management. This report highlights a unique and severe case of bilateral keratouveitis with glaucoma following a systemic inflammatory event.<\/jats:p>","DOI":"10.1111\/vop.70278","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:05:00Z","timestamp":1791014700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Keratouveitis and Secondary Glaucoma in a Young Dog With Immune\u2010Mediated Polyarthritis and Systemic Inflammatory Response Syndrome"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0583-5763","authenticated-orcid":false,"given":"Sahana N.","family":"Prabhu","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5908-4606","authenticated-orcid":false,"given":"Amanda B.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8892-1821","authenticated-orcid":false,"given":"Kelsey R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-7720","authenticated-orcid":false,"given":"Georgina M.","family":"Newbold","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1090","volume-title":"Veterinary Ophthalmology","author":"Whitely R. 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