{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:54Z","timestamp":1792471134038,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Contrast\u2010enhanced ultrasonography (CEUS) is a noninvasive and relatively safe imaging technique to assess ocular perfusion, showing high sensitivity and specificity for tumor characterization in human oncology, while reports on its application in canine and feline diseased eyes are limited. This study aimed to describe the CEUS features of orbital and intraocular pathologies in dogs and cats in order to evaluate its diagnostic value in detecting and characterizing various lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animal Studied<\/jats:title>\n                    <jats:p>CEUS examinations of 30 animals (24 dogs, 6 cats) were evaluated retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>Following B\u2010mode ultrasonography, CEUS examinations utilizing sulfur hexafluoride were performed. Pathologies were categorized in one of the following groups: orbital neoplastic lesions, orbital inflammatory lesions, intraocular neoplastic lesions, intraocular inflammatory lesions and retinal detachment. Qualitative perfusion parameters, contrast intensity, enhancement pattern, perfusion type and time to wash\u2010in and wash\u2010out were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CEUS detected vascularization in orbital and intraocular pathologies, with variable enhancement characteristics. Persistent vascularization was observed in all cases of retinal detachment. In orbital and intraocular neoplastic lesions, CEUS improved lesion localization, assessment of interactions with surrounding tissues and tissue perfusion. For inflammatory pathologies such as abscesses, myositis, and steatitis, the additional diagnostic value of CEUS compared to B\u2010mode ultrasonography was limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings indicated that CEUS could identify a variety of orbital and intraocular pathologies and provided additional diagnostic information to B\u2010mode ultrasonography, particularly for assessing neoplastic lesions and retinal detachments. CEUS has the potential to enhance ophthalmic ultrasonography in differentiating specific pathologies. Prospective studies are warranted to further evaluate its clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70281","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:51:34Z","timestamp":1792468294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast\u2010Enhanced Ultrasonography of Orbital and Intraocular Pathologies in 24 Dogs and 6 Cats"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6984-156X","authenticated-orcid":false,"given":"Janneke I.","family":"Ortner","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Department of Companion Animals and Horses University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4443-2588","authenticated-orcid":false,"given":"Katharina M.","family":"Hittmair","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging, Department of Companion Animals and Horses University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Nell","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Companion Animals and Horses University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-7740","authenticated-orcid":false,"given":"Klaas\u2010Ole","family":"Blohm","sequence":"additional","affiliation":[{"name":"Tierklinik Neust\u00e4dter Bucht  Sierksdorf Germany"},{"name":"Tierarztpraxis Sch\u00f6nhoff  Stendal Germany"},{"name":"Tierklinik L\u00fcsche im SANAKENA  Appen\u2010Etz Germany"},{"name":"Pferdeklinik Bargteheide  Bargteheide Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1740-8261.1987.tb01726.x","article-title":"Two\u2010Dimensional Real\u2010Time Ocular Ultrasonography in the Dog","volume":"28","author":"Hager D. 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