{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:24:43Z","timestamp":1777159483393,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Ferritin levels are often highly elevated at birth in neonates with alloimmune haemolytic disease of the fetus and newborn (<jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>). Data on ferritin levels in these infants in the first 3\u00a0months of life are lacking. Objective of this study was to examine the course of iron status and incidence of iron deficiency and overload in neonates with alloimmune <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content> up to 3\u00a0months of age. Secondary objective was to analyse bilirubin levels, liver enzymes and red\u2010blood\u2010cell indices in the same time period and the association with intrauterine transfusion (<jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Observational study of neonates with alloimmune <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content> admitted to our centre between <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2010 and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2012. Data on iron status, bilirubin levels, liver enzymes and red\u2010blood\u2010cell indices up to 3\u00a0months of age were routinely collected and compared between neonates treated with and without <jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five infants with alloimmune <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content> were included. Iron overload occurred in 70% of neonates at birth and in 50% and 18% at the age of 1 and 3\u00a0months, respectively. No cases of iron deficiency at birth and only one case of iron deficiency at 3\u00a0months of age were found. No infants received iron therapy. Infants who received <jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content> had a significantly lower haemoglobin level and reticulocyte count and higher ferritin level at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The vast majority of neonates with alloimmune <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content> have iron overload at birth. Incidence of iron overload gradually decreases within the first 3\u00a0months without iron supplementation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12061","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T09:38:49Z","timestamp":1372325929000},"page":"328-333","source":"Crossref","is-referenced-by-count":24,"title":["Iron status in infants with alloimmune haemolytic disease in the first three months of life"],"prefix":"10.1111","volume":"105","author":[{"given":"M. E. A.","family":"Rath","sequence":"first","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. E. H. J.","family":"Smits\u2010Wintjens","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Department of Obstetrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Walther","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.07.010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010490440464"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90997-J"},{"key":"e_1_2_5_5_1","first-page":"558","article-title":"The effect of intrauterine intravascular blood transfusion on iron metabolism in fetuses with Rh alloimmunization","volume":"77","author":"Nasrat HA","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264247"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994390"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200458"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100805"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0120-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1723"},{"key":"e_1_2_5_12_1","first-page":"349","article-title":"Intrauterine growth and intrauterine growth curves","volume":"69","author":"Kloosterman GJ","year":"1969","journal-title":"Ned Tijdschr Verloskd Gynaecol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.01.002"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014026"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200408000-00001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1521-7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000212906.07018.93"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00931.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.109"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.536866"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.700"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335333"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12061","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T17:43:26Z","timestamp":1696009406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/vox.12061"],"URL":"https:\/\/doi.org\/10.1111\/vox.12061","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}