{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:44:34Z","timestamp":1696164274109},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Transfusions of pooled or apheresis platelets are seen as equally effective in increasing platelet counts with similar rates of transfusion reactions. It has been suggested that allergic transfusion reactions (<jats:styled-content style=\"fixed-case\">ATR<\/jats:styled-content>s) to platelets are associated with recipient and donor factors. In this study, we assessed differences in <jats:styled-content style=\"fixed-case\">ATR<\/jats:styled-content> rates among individuals who received platelet components at two academic medical centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 45\u00a0189 leukoreduced platelet products were transfused during the study period of which 31\u00a0748 were apheresis units and 13\u00a0441 were pooled units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transfusion reactions were reported in 0\u00b76% (277 of 45\u00a0189) of platelet transfusions. The reaction rate was significantly higher in pooled (102 of 13\u00a0441) than in apheresis (175 of 31\u00a0748) (0\u00b776% vs. 0\u00b755%, respectively, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b701) components. However, an analysis of reactions by categories indicated that only the <jats:styled-content style=\"fixed-case\">ATR<\/jats:styled-content> rate was significantly higher in pooled (55 of 13\u00a0441) products as compared with apheresis (76 of 31\u00a0748) (0\u00b741% vs. 0\u00b724%, respectively, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70029) platelets. Moreover, there was no difference in the rate of ABO mismatch between pooled and apheresis products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that pooled platelet components are associated with higher <jats:styled-content style=\"fixed-case\">ATR<\/jats:styled-content> rates than apheresis platelets, suggesting that these components may not be completely equivalent from the standpoint of adverse events. Further investigation is needed to address whether differences in <jats:styled-content style=\"fixed-case\">ATR<\/jats:styled-content>s are related to the pooling process or the extent of donor antigen exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12063","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T09:36:54Z","timestamp":1372325814000},"page":"334-340","source":"Crossref","is-referenced-by-count":11,"title":["Allergic transfusion reactions to platelets are more commonly associated with prepooled than apheresis components"],"prefix":"10.1111","volume":"105","author":[{"given":"W.","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospitals Case Medical Center Cleveland OH USA"},{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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