{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T21:25:42Z","timestamp":1699133142711},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Retrospective publications show a decrease in the bleeding frequency and an improvement in the quality of life (QoL) in severe adult haemophilia A (<jats:styled-content style=\"fixed-case\">SAHA<\/jats:styled-content>) after switching from the on\u2010demand treatment (<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>) to secondary prophylaxis (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>). But there are no prospective studies which demonstrate, using a haemophilia\u2010specific questionnaire, an improvement in the QoL after such treatment change. The main objective of this study is to prospectively compare the QoL and the musculoskeletal assessment after switching from <jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SAHA<\/jats:styled-content> using the A36 Hemofilia\u2010QoL<jats:sup>\u00ae<\/jats:sup>. As secondary objective, we compare the haemarthrosis frequency and factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> consumption in <jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> during a similar period of time (12\u00a0months) after switching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We have designed a prospective study including <jats:styled-content style=\"fixed-case\">SAHA<\/jats:styled-content> who have been under <jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content> and were changed to a protocol, which combines <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> (biweekly administration of factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>) with individualized physiotherapy programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve months after switching to <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>, the QoL was significantly improved (<jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b7005). Musculoskeletal assessment of pathologic irreversible joints and joints with a reversible alteration was generally improved, although in only a few joints, this improvement was statistically significant. Haemarthrosis was strongly reduced (12\u00b760\u20131\u00b742, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b7001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This prospective study has demonstrated a statistically significant improvement in the QoL after 1\u00a0year from switching patients from <jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>. The musculoskeletal assessment after 1\u00a0year was maintained similar or slightly improved. When we compared retrospective <jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content> and prospective <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>, haemarthrosis where strongly reduced requiring a slight increase in the consumption of factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> concentrates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12066","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T09:38:42Z","timestamp":1372325922000},"page":"68-74","source":"Crossref","is-referenced-by-count":14,"title":["Secondary prophylaxis vs. on\u2010demand treatment to improve quality of life in severe adult haemophilia A patients: a prospective study in a single centre"],"prefix":"10.1111","volume":"106","author":[{"given":"J. A.","family":"Aznar","sequence":"first","affiliation":[{"name":"Haemostasis and Thrombosis Unit Haematology and Haemotherapy Service La Fe University and Polytechnic Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Garc\u00eda\u2010Das\u00ed","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Haematology and Haemotherapy Service La Fe University and Polytechnic Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"P\u00e9rez\u2010Alenda","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Haematology and Haemotherapy Service La Fe University and Polytechnic Hospital Valencia Spain"},{"name":"Physiotherapy Department University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Marco","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Haematology and Haemotherapy Service La Fe University and Polytechnic Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jaca","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Haematology and Haemotherapy Service La Fe University and Polytechnic Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Moret","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Haematology and Haemotherapy Service La Fe University and Polytechnic Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Querol","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Haematology and Haemotherapy Service La Fe University and Polytechnic Hospital Valencia Spain"},{"name":"Physiotherapy Department University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1998.00396.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00397.x"},{"issue":"1","key":"e_1_2_6_6_1","first-page":"0R205","article-title":"Late prophylaxis for severe hemophilia: effects of prophylaxis started in adulthood","volume":"3","author":"Fischer K","year":"2005","journal-title":"J Thromb Haemost"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03650.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04611.x"},{"issue":"4","key":"e_1_2_6_9_1","first-page":"13","article-title":"A36 Hemofilia\u2010QoL\u00ae: una herramienta \u00fatil para la evaluaci\u00f3n de la calidad de vida en pacientes adultos con hemofilia","volume":"91","author":"Remor E","year":"2006","journal-title":"Haematologica (Spanish Ed)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01144.x"},{"key":"e_1_2_6_11_1","first-page":"3","article-title":"Prophylaxis: musculoskeletal evaluation","volume":"30","author":"Gilbert MS","year":"1993","journal-title":"Semin Hematol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1981.tb05741.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02883.x"},{"key":"e_1_2_6_14_1","first-page":"637","article-title":"Effect of antihemophilic factor on one\u2010stage clotting tests; 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