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The alloimmunization risk could depend on multiple factors such as the number of transfusions and, most of all, the genetic background. Different ethnic groups are predisposed to immunization because of a significant degree of <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> antigenic mismatch between donor and recipient. There is no universal agreement and standards for the most appropriate selection of <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> units in chronically transfused subjects. Current practice only deals with compatibility of <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>, Rh and K antigens. Molecular <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> antigenic matching extended to other blood group systems is an innovative strategy to ensure a better quality and effectiveness of transfusion therapy.<\/jats:p>","DOI":"10.1111\/vox.12086","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:44:35Z","timestamp":1381545875000},"page":"197-208","source":"Crossref","is-referenced-by-count":84,"title":["Red blood cell alloimmunization in sickle cell disease and in thalassaemia: current status, future perspectives and potential role of molecular typing"],"prefix":"10.1111","volume":"106","author":[{"given":"A.","family":"Matteocci","sequence":"first","affiliation":[{"name":"Immunohematology and Transfusion Medicine Unit Transfusion Medicine Department San Camillo Forlanini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pierelli","sequence":"additional","affiliation":[{"name":"Immunohematology and Transfusion Medicine Unit Transfusion Medicine Department San Camillo Forlanini Hospital Rome Italy"},{"name":"Department of Experimental Medicine Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-327361"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07285.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12061"},{"key":"e_1_2_10_5_1","unstructured":"Bolton\u2010MaggsP CohenH WattA et\u00a0al.:Annual SHOT report 2011. 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