{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:04:10Z","timestamp":1789203850139,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2014,4]]},"abstract":"\n Background and Objectives<\/jats:title>\n \n Platelet\u2010derived microparticles (\n PMP<\/jats:styled-content>\n s) and other proinflammatory mediators, which are accumulated during the storage process, might induce transfusion adverse events. We hypothesized that the\n PMP<\/jats:styled-content>\n primed polymorphonuclear neutrophil (\n PMN<\/jats:styled-content>\n ) respiratory burst after the transfusion, which could be linked to the transfusion\u2010related acute lung injury (\n TRALI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n The\n PMP<\/jats:styled-content>\n s were isolated by centrifugation of the platelet\u2010free plasma from 10 apheresis platelet concentrates (A\u2010\n PLT<\/jats:styled-content>\n s) at 20\u00a0000\u00a0\u00d7\u00a0g for 1\u00a0h. The\n PMP<\/jats:styled-content>\n s were counted by flow cytometric analysis, followed by\n W<\/jats:styled-content>\n estern blotting, that were performed on isolated\n PMP<\/jats:styled-content>\n s. The soluble CD40 ligand (\n sCD<\/jats:styled-content>\n 40L,\n sCD<\/jats:styled-content>\n 154) was assayed with\n ELISA<\/jats:styled-content>\n . The priming of the formyl\u2010Met\u2010Leu\u2010Phe (\n fMLP<\/jats:styled-content>\n )\u2010activated\n PMN<\/jats:styled-content>\n respiratory burst was measured with the hydrogen peroxide production.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n PMP<\/jats:styled-content>\n counts increased by 1\u00b77\u2010folds after 3\u00a0days of storage. Meanwhile,\n sCD<\/jats:styled-content>\n 40L also significantly increased in\n PMP<\/jats:styled-content>\n fraction isolated from the 3\u2010day stored A\u2010\n PLT<\/jats:styled-content>\n s. Furthermore,\n W<\/jats:styled-content>\n estern blotting indicated that\n sCD<\/jats:styled-content>\n 40L was involved and concentrated in\n PMP<\/jats:styled-content>\n . The\n PMP<\/jats:styled-content>\n s were able to effectively prime the\n fMLP<\/jats:styled-content>\n \u2010activated\n PMN<\/jats:styled-content>\n respiratory burst, which was partly inhibited by CD154 monoclonal antibody or by filtration with 0\u00b71\u00a0\u03bc\n m<\/jats:sc>\n membrane. Significant relativity was existed between the\n PMP<\/jats:styled-content>\n counts,\n sCD<\/jats:styled-content>\n 40L and priming activity during the A\u2010\n PLT<\/jats:styled-content>\n storage.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The platelet\u2010derived microparticles, which carried the\n sCD<\/jats:styled-content>\n 40L, accumulated in the apheresis platelet concentrates during the 5\u00a0days of storage. They primed the\n fMLP<\/jats:styled-content>\n \u2010activated\n PMN<\/jats:styled-content>\n respiration burst, which might be relative to\n TRALI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.12092","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T04:14:42Z","timestamp":1382328882000},"page":"234-241","source":"Crossref","is-referenced-by-count":31,"title":["The effect of platelet\u2010derived microparticles in stored apheresis platelet concentrates on polymorphonuclear leucocyte respiratory burst"],"prefix":"10.1111","volume":"106","author":[{"given":"R. F.","family":"Xie","sequence":"first","affiliation":[{"name":"The Blood Engineering Laboratory Shanghai Blood Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hu","sequence":"additional","affiliation":[{"name":"The Institute of Life Science East China Normal University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Li","sequence":"additional","affiliation":[{"name":"The Institute of Life Science East China Normal University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. N.","family":"Ren","sequence":"additional","affiliation":[{"name":"The Blood Engineering Laboratory Shanghai Blood Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yang","sequence":"additional","affiliation":[{"name":"The Blood Engineering Laboratory Shanghai Blood Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. M.","family":"Yang","sequence":"additional","affiliation":[{"name":"The Blood Engineering Laboratory Shanghai Blood Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"The Blood Engineering Laboratory Shanghai Blood Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. H.","family":"Fan","sequence":"additional","affiliation":[{"name":"The Blood Engineering Laboratory Shanghai Blood Center Shanghai 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