{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:54:18Z","timestamp":1763535258611},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neonates after perinatal asphyxia are at increased risk of thrombocytopenia. The correlation between perinatal asphyxia and the risk and severity of early\u2010onset thrombocytopenia is not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the incidence, severity and risk factors for early\u2010onset thrombocytopenia in neonates after perinatal asphyxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all newborns (gestational age\u00a0\u2265\u00a036\u00a0weeks) admitted to our neonatal nursery due to perinatal asphyxia in this retrospective study. We collected platelet counts that were obtained within the first 48\u00a0h of life to estimate the incidence and severity of early\u2010onset thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total number of 171 neonates with perinatal asphyxia were included in the study. The incidence of early\u2010onset thrombocytopenia (platelet count\u00a0&lt;\u00a0150\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l) was 51% (87\/171). Several factors were associated with increased risk of early\u2010onset thrombocytopenia, including prolonged prothrombin time (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>) [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1\u00b718, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1\u00b708\u20131\u00b730, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701], prolonged activated partial thromboplastin time (<jats:styled-content style=\"fixed-case\">APTT<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1\u00b707, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b703\u20131\u00b711, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701), low Apgar score at 10\u00a0min (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1\u00b725, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b708\u20131\u00b745, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) and high serum lactate (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1\u00b712, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b706\u20131\u00b719, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701). After multiple logistic regression analysis, we found an independent association between early\u2010onset thrombocytopenia and prolonged <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1\u00b715, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b700\u20131\u00b733, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7045) and higher lactate level (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1\u00b715, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b703\u20131\u00b728, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early\u2010onset thrombocytopenia occurs frequently in neonates after perinatal asphyxia and is independently associated with <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> and lactate level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12105","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T11:45:38Z","timestamp":1383047138000},"page":"361-367","source":"Crossref","is-referenced-by-count":11,"title":["Early\u2010onset thrombocytopenia in near\u2010term and term infants with perinatal asphyxia"],"prefix":"10.1111","volume":"106","author":[{"given":"N.","family":"Boutaybi","sequence":"first","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Steggerda","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. E. H. J.","family":"Smits\u2010Wintjens","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. W.","family":"van Zwet","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Walther","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200302000-00004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2004.10.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-11-16"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70044-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0582"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)81059-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02751717"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250202"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02751717"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.4.885"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.43"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.06.015"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-0038-1642563","article-title":"The effect of hypoxia on platelet survival and site of sequestration in the newborn rabbit","volume":"59","author":"Castle V","year":"1988","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_18_1","first-page":"230","article-title":"Hypoxia\u2010induced thrombocytopenia in mice","volume":"86","author":"Birks JW","year":"1975","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199907000-00005"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051155"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb01334.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.76.1.F15"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0332"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:39:41Z","timestamp":1695551981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/vox.12105"],"URL":"https:\/\/doi.org\/10.1111\/vox.12105","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]}}}