{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:18:22Z","timestamp":1776835102032,"version":"3.51.2"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T00:00:00Z","timestamp":1386892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pierre Fabre M\u00ef\u00bf\u00bddicament, Boulogne, France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Restless legs syndrome (<jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content>) is a frequent condition with a prevalence of 5\u201315% in the general population. Clinical and genetic observations have shown that iron deficiency, highly prevalent among blood donors, can be related to <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content>. The objective of this study was to assess the prevalence of <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> in female blood donors 1\u00a0week after blood donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One week after blood donation, 291 female blood donors, aged &lt;50\u00a0years, self\u2010responded to all four <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> questions defined by the 1995 International <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> study group. Blood donation rate, fatigue, aerobic capacity, menstruation, mood disorder and quality of life were also assessed along with haemoglobin and ferritin blood concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> in female blood donors 1\u00a0week after blood donation was 6\u00b79% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 4\u00b72\u201310\u00b74%). Female blood donors with <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> had a higher prevalence of hyper\u2010menorrhaea (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7033) and were significantly more tired (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001). We observed no associations between <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> and number of previous donations (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7409), aerobic capacity (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7476), mood disorder (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7169), quality of life (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7356), haemoglobin (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7087), and serum ferritin level (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7446).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Restless legs syndrome prevalence in female blood donors is not as important as described in some other studies, which could reassure blood donors. The prevalence of hypermenorrhaea and fatigue is higher in <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> blood donors. Therefore, screening for fatigue and hypermenorrhaea could be considered as these symptoms are associated with <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> in female blood donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12123","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T11:37:21Z","timestamp":1386934641000},"page":"44-49","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence of restless legs syndrome in female blood donors 1\u00a0week after blood donation"],"prefix":"10.1111","volume":"107","author":[{"given":"B.","family":"Pedrazzini","sequence":"first","affiliation":[{"name":"Department of Ambulatory Care and Community Medicine University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Waldvogel","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service of the Swiss Red Cross Lausanne 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