{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:39:30Z","timestamp":1764995970542},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Transfusion\u2010associated anaphylaxis (<jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>) is a severe adverse reaction reported to occur in 1:9000\u201390\u00a0000 transfusions. According to the Danish Registration of Transfusion Risks (<jats:styled-content style=\"fixed-case\">DART<\/jats:styled-content>), the frequency is 1:300\u00a0000 transfusions, which suggests insufficient reporting of <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> in Denmark. Our aims were to identify possible cases of <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>, to characterize their symptoms and tryptase levels and to investigate the reporting of <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> to the haemovigilance systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We reviewed 245 patients with suspected allergic reactions during anaesthesia and surgery, investigated at the Danish Anaesthesia Allergy Centre (<jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content>). Based on the outcome of this investigation, the patients were classified as <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content> positive (confirmed hypersensitivity to identified agent, <jats:italic>n<\/jats:italic>\u00a0=\u00a0112), or <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content> negative (no confirmed hypersensitivity, <jats:italic>n<\/jats:italic>\u00a0=\u00a0133). Data on case history, details of blood transfusion and results of laboratory and clinical investigations were collected. <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> cases were identified according to the recommendations of the International Society of Blood Transfusion (<jats:styled-content style=\"fixed-case\">ISBT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten possible <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> cases (30% of all transfused patients) were identified, all <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content> negative. The frequency of elevated serum tryptase, hypotension and male sex was significantly higher among these cases compared with the remaining <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content> negative (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), but not different from the <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content>\u2010positive patients. One case had been reported to the Blood Bank haemovigilance system and none to <jats:styled-content style=\"fixed-case\">DART<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified unreported cases of possible <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>, which resembled the <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content>\u2010positive patients with respect to elevated tryptase and symptoms. By applying the <jats:styled-content style=\"fixed-case\">ISBT<\/jats:styled-content> criteria of adverse transfusion reactions, we conclude that <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> during anaesthesia and surgery is likely to be underreported in Denmark.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12133","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T23:53:55Z","timestamp":1392854035000},"page":"158-165","source":"Crossref","is-referenced-by-count":8,"title":["Transfusion\u2010associated anaphylaxis during anaesthesia and surgery \u2013 a retrospective study"],"prefix":"10.1111","volume":"107","author":[{"given":"G.","family":"Lindsted","sequence":"first","affiliation":[{"name":"Section for Transfusion Medicine Capital Region Blood Bank Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"},{"name":"Danish Anaesthesia Allergy Centre Allergy Clinic Copenhagen University Hospital Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Section for Transfusion Medicine Capital Region Blood Bank Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kr\u00f8igaard","sequence":"additional","affiliation":[{"name":"Danish Anaesthesia Allergy Centre Allergy Clinic Copenhagen University Hospital Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Garvey","sequence":"additional","affiliation":[{"name":"Danish Anaesthesia Allergy Centre Allergy Clinic Copenhagen University Hospital Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. K.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Danish Anaesthesia Allergy Centre Allergy Clinic Copenhagen University Hospital Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mosbech","sequence":"additional","affiliation":[{"name":"Danish Anaesthesia Allergy Centre Allergy Clinic Copenhagen University Hospital Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"The Department of Clinical Immunology\/Blood Bank Aarhus University Hospital Skejby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Norgaard","sequence":"additional","affiliation":[{"name":"Section for Transfusion Medicine Capital Region Blood Bank Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-0316-ATR"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200311000-00004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-009-9115-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12150"},{"key":"e_1_2_6_6_1","unstructured":"Working Party on Haemovigilance \u2013 Proposed Standard Definitions for Surveillance of Non Infectious Adverse Transfusion Reactions2011.ISBT \u2013 International Society of Blood Transfusion. 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