{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:21:55Z","timestamp":1769066515743,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Optimization of the preoperative hemoglobin (Hb) level is an effective way to reduce allogeneic transfusion in total knee arthroplasty (<jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>) though the procedure is expensive, requires close monitoring and is often inconvenient for patients with reduced mobility. Our aim was to investigate the value of preoperative Hb levels to predict transfusion and thereby tailoring Hb optimization to patient characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All consecutive patients who undergone primary <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content> in our center over 2\u00a0years, and received tranexamic acid intraoperatively, were reviewed. The adjusted association between preoperative Hb levels and transfusion was assessed by multivariate logistic regression, and the estimated probability of transfusion for individual patients was derived from the logistic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 784 patients who meet the inclusion criteria, risk of transfusion was associated with poorer performance status, as measured by the America Association of Anestesiology (<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>) score <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3\u00b73, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and lower preoperative Hb level (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3\u00b78 for each g\/dl below 13\u00a0g\/dl; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). According to the Hb level, the estimated probability of transfusion was 0\u00b703 (range: 0\u00b703\u20130\u00b764) for <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> I\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> patients and 0\u00b710 (range: 0\u00b710\u20130\u00b784) for <jats:styled-content style=\"fixed-case\">ASA III<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Not all the patients undergoing <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content> who receive tranexamic acid need the same preoperative Hb optimization target. Two easily available factors, such as the <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> score and the Hb level, can help individualize the Hb optimization target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12147","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T04:29:20Z","timestamp":1396240160000},"page":"148-152","source":"Crossref","is-referenced-by-count":20,"title":["Should all patients be optimized to the same preoperative hemoglobin level to avoid transfusion in primary knee arthroplasty?"],"prefix":"10.1111","volume":"107","author":[{"given":"M.","family":"Basora","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ti\u00f3","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"S\u00e1nchez\u2010Etayo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Raquel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Hemotherapy and Hemostasis Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2001.00291.x"},{"key":"e_1_2_6_3_1","first-page":"18","article-title":"Risk factors for transfusion in primary knee arthroplasty","volume":"53","author":"Biarn\u00e9s A","year":"2006","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"e_1_2_6_4_1","first-page":"24","article-title":"A prospective audit of blood usage post primary total knee arthroplasty","volume":"72","author":"Glynn A","year":"2006","journal-title":"Acta Orthop Belg"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2003.10.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37597293874.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.381098440857.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000132928.45858.92"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790080309"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200202000-00008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199812000-00008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00698.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq361"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.09.015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.93B12.26989"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00873"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1754-z"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01564.x"},{"key":"e_1_2_6_19_1","unstructured":"European Medicine Agency.The European Commission issued a decision for tranexamic acid 10 October2012. 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