{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:42:47Z","timestamp":1791423767125,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n Present platelet storage media often designated platelet additive solutions (\n PAS<\/jats:styled-content>\n ) basically contain acetate, citrate and phosphate and recently also potassium and magnesium. However, there seems to be an increasing interest in developing\n PAS<\/jats:styled-content>\n s that can be used also after further reduction of residual plasma content below 15\u201320% plasma. Inclusion of glucose but also calcium and bicarbonate in such solutions have been suggested to improve platelet (\n PLT<\/jats:styled-content>\n ) storage, especially when plasma content is reduced to very low levels. Results from a limited number of studies using novel\n PAS<\/jats:styled-content>\n alternatives have been presented during the last years, such as\n I<\/jats:styled-content>\n nter\n S<\/jats:styled-content>\n ol\u2010\n G<\/jats:styled-content>\n ,\n PAS<\/jats:styled-content>\n \u20105,\n M<\/jats:styled-content>\n \u2010sol,\n PAS<\/jats:styled-content>\n \u2010\n G<\/jats:styled-content>\n and\n SAS<\/jats:styled-content>\n . Most of them are experimental solutions. The combined results presented in those studies suggest that presence of glucose may be necessary during\n PLT<\/jats:styled-content>\n storage, primarily to maintain\n ATP<\/jats:styled-content>\n at acceptable levels. At plasma inclusion below 15\u201320%, the content of glucose will generally be too low to support\n PLT<\/jats:styled-content>\n metabolism for more than a few days making glucose addition in\n PAS<\/jats:styled-content>\n necessary. Significant effects associated with presence of calcium was observed in\n PLT<\/jats:styled-content>\n s stored in\n PAS<\/jats:styled-content>\n with 5% inclusion but not with 20\u201335% plasma inclusion, suggesting that the content of plasma could be of importance. Bicarbonate only seems to be of importance for p\n H<\/jats:styled-content>\n regulation, primarily when plasma inclusion is reduced to about 5%. Reduction in rate of glycolysis was observed in some\n PAS<\/jats:styled-content>\n alternatives containing potassium and magnesium but not in others. Differences in p\n H<\/jats:styled-content>\n or in concentrations of the various compounds included in\n PAS<\/jats:styled-content>\n may be possible explanations. Additionally, novel\n PAS<\/jats:styled-content>\n containing glucose, calcium and bicarbonate does not seem to be associated with improved\n in vitro<\/jats:italic>\n results as compared to\n SSP<\/jats:styled-content>\n + or\n C<\/jats:styled-content>\n ompo\n S<\/jats:styled-content>\n ol when\n PLT<\/jats:styled-content>\n s are stored with 35% plasma inclusion. The results would then also suggest that excess of glucose in novel\n PAS<\/jats:styled-content>\n environment may not be associated with additional positive effects on\n PLT<\/jats:styled-content>\n metabolism. This review is based on the few publications on novel\n PAS<\/jats:styled-content>\n available, and additional studies would be needed in the future.\n <\/jats:p>","DOI":"10.1111\/vox.12172","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T05:35:22Z","timestamp":1403847322000},"page":"205-212","source":"Crossref","is-referenced-by-count":83,"title":["Platelet storage media"],"prefix":"10.1111","volume":"107","author":[{"given":"H.","family":"Gulliksson","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Transfusion Medicine Karolinska University Hospital, and Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"421","article-title":"Effect of additive solutions on platelet biochemistry","volume":"18","author":"Holme S","year":"1992","journal-title":"Blood Cells"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-3886(94)90086-8"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-3886(94)90167-8"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(99)80029-7"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2000.00262.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(03)00020-8"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2003.00449.x"},{"key":"e_1_2_4_9_1","first-page":"135","volume-title":"Blood Component Preparation. 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