{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:56:14Z","timestamp":1785117374151,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>An Australian Caucasian blood donor consistently presented a serology profile for the Duffy blood group as Fy(a+b+) with Fy<jats:sup>a<\/jats:sup> antigen expression weaker than other examples of Fy(a+b+) red cells. Molecular typing studies were performed to investigate the reason for the observed serology profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Blood group genotyping was performed using a commercial <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> microarray platform. Sanger sequencing was performed using primer sets to amplify across exons 1 and 2 of the <jats:italic><jats:styled-content style=\"fixed-case\">FY<\/jats:styled-content><\/jats:italic> gene and using allele\u2010specific primers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The propositus was genotyped as <jats:italic><jats:styled-content style=\"fixed-case\">FY<\/jats:styled-content>*A\/B, <jats:styled-content style=\"fixed-case\">FY<\/jats:styled-content>*X heterozygote<\/jats:italic> that predicted the Fy(a+b+<jats:sup>w<\/jats:sup>) phenotype. Sequencing identified the 265T and 298A variants on the <jats:italic><jats:styled-content style=\"fixed-case\">FY<\/jats:styled-content>*A<\/jats:italic> allele. This link between <jats:italic><jats:styled-content style=\"fixed-case\">FY<\/jats:styled-content>*A<\/jats:italic> allele and 265T was confirmed by allele\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reduced Fy<jats:sup>a<\/jats:sup> antigen reactivity is attributed to a <jats:italic><jats:styled-content style=\"fixed-case\">FY<\/jats:styled-content>*A<\/jats:italic> allele\u2010carrying 265T and 298A variants previously defined in combination only with the <jats:italic><jats:styled-content style=\"fixed-case\">FY<\/jats:styled-content>*B<\/jats:italic> allele and associated with weak Fy<jats:sup>b<\/jats:sup> antigen expression. This novel allele should be considered in genotyping interpretative algorithms for generating a predicted phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12185","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T03:52:58Z","timestamp":1407210778000},"page":"52-57","source":"Crossref","is-referenced-by-count":14,"title":["A novel <i><scp>FY<\/scp>*A<\/i> allele with the 265T and 298A <scp>SNP<\/scp>s formerly associated exclusively with the <i><scp>FY<\/scp>*B<\/i> allele and weak Fy<sup>b<\/sup> antigen expression: implication for genotyping interpretative algorithms"],"prefix":"10.1111","volume":"108","author":[{"given":"G. H.","family":"Lopez","sequence":"first","affiliation":[{"name":"Research and Development Australian Red Cross Blood Service Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Condon","sequence":"additional","affiliation":[{"name":"Red Cell Reference Laboratory Australian Red Cross Blood Service West Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Red Cell Reference Laboratory Australian Red Cross Blood Service Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Red Cell Reference Laboratory Australian Red Cross Blood Service Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010W.","family":"Liew","sequence":"additional","affiliation":[{"name":"Red Cell Reference Laboratory Australian Red Cross Blood Service Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Flower","sequence":"additional","affiliation":[{"name":"Research and Development Australian Red Cross Blood Service Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Hyland","sequence":"additional","affiliation":[{"name":"Research and Development Australian Red Cross Blood Service Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05202.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.1.44.44"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.2.701"},{"key":"e_1_2_8_5_1","volume-title":"The Blood Group Antigen Facts Book","author":"Reid ME","year":"2012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1955.tb05523.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0695-224"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.1.378.378"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13973"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-115"},{"key":"e_1_2_8_11_1","first-page":"384","article-title":"The Duffy blood group system in Caucasians: evidence for a new allele","volume":"17","author":"Chown B","year":"1965","journal-title":"Am J Hum Genet"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.1997.d01-16.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2004.00554.x"},{"key":"e_1_2_8_14_1","unstructured":"International Society for Blood Transfusion.Names for FY (ISBT 008) Blood Group Alleles. 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