{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:47:18Z","timestamp":1791269238516,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T00:00:00Z","timestamp":1408320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Background and Objectives<\/jats:title>Post\u2010transfusion reactions with dyspnoea (PTR<\/jats:styled-content>) are major causes of morbidity and death after blood transfusion. Transfusion\u2010related acute lung injury (TRALI<\/jats:styled-content>) and transfusion\u2010associated circulatory overload (TACO<\/jats:styled-content>) are most dangerous, while transfusion\u2010associated dyspnoea (TAD<\/jats:styled-content>) is a milder respiratory distress. We investigated blood components for immune and non\u2010immune factors implicated in PTR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>We analysed 464 blood components (RBCs, PLTs, L\u2010PLTs, FFP) transfused to 271 patients with PTR. Blood components were evaluated for 1\/antileucocyte antibodies, 2\/cytokines: IL\u20101\u03b2, IL\u20106, IL\u20108, TNF\u2010\u03b1, sCD40L, 3\/lysophosphatidylcholines (LysoPCs), 4\/microparticles (MPs) shed from plateletes (PMPs), erythrocytes (EMPs) and leucocytes (LMPs).<\/jats:p><\/jats:sec>Results<\/jats:title>Anti\u2010HLA<\/jats:styled-content> class I\/II<\/jats:styled-content> antibodies or granulocyte\u2010reactive anti\u2010HLA<\/jats:styled-content> antibodies were detected in 18\u00b72% of blood components (RBC<\/jats:styled-content> and FFP<\/jats:styled-content>) transfused to TRALI<\/jats:styled-content> and in 0\u00b75% of FFP<\/jats:styled-content> transfused to TAD<\/jats:styled-content> cases. Cytokines and LysoPC<\/jats:styled-content>s concentrations in blood components transfused to PTR<\/jats:styled-content> patients did not exceed those in blood components transfused to patients with no PTR<\/jats:styled-content>. Only EMP<\/jats:styled-content>s percentage in RBC<\/jats:styled-content>s transfused to patients with TRALI<\/jats:styled-content> was significantly higher (P<\/jats:italic>\u00a0<\u00a00\u00b705) than in RBC<\/jats:styled-content>s transfused to patients with no PTR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Immune character of PTR<\/jats:styled-content> was confirmed mainly in 1\/5 TRALI<\/jats:styled-content> cases. Among non\u2010immune factors, only MP<\/jats:styled-content>s released from stored RBC<\/jats:styled-content>s are suggested as potential mediators of TRALI<\/jats:styled-content>. Our results require further observations in a more numerous and better defined group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12190","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T04:03:25Z","timestamp":1408421005000},"page":"27-36","source":"Crossref","is-referenced-by-count":25,"title":["Analysis of leucocyte antibodies, cytokines, lysophospholipids and cell microparticles in blood components implicated in post\u2010transfusion reactions with dyspnoea"],"prefix":"10.1111","volume":"108","author":[{"given":"K.","family":"Ma\u015blanka","sequence":"first","affiliation":[{"name":"Department of Immunohematology and Immunology of Transfusion Medicine Institute of Hematology and Transfusion Medicine Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Uhrynowska","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Immunology of Transfusion Medicine Institute of 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