{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:11:57Z","timestamp":1780315917286,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Background and Objectives<\/jats:title>Febrile non\u2010haemolytic transfusion reaction (FNHTR<\/jats:styled-content>) is an acute transfusion complication resulting in fever, chills and\/or rigours. Study's objective was to assess FNHTR<\/jats:styled-content> occurrence and potential risk factors among inpatient U<\/jats:styled-content>.S<\/jats:styled-content>. elderly M<\/jats:styled-content>edicare beneficiaries, ages 65 and older, during 2011\u20132012.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Our retrospective claims\u2010based study utilized large M<\/jats:styled-content>edicare administrative databases. FNHTR<\/jats:styled-content> was ascertained via ICD<\/jats:styled-content>\u20109\u2010CM<\/jats:styled-content> diagnosis code, and transfusions were identified by recorded procedure and revenue centre codes. The study ascertained FNHTR<\/jats:styled-content> rates among the inpatient elderly overall and by age, gender, race, blood components and units transfused. Multivariate logistic regression analyses were used to assess potential risk factors.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 4\u00a0336\u00a0338 inpatient transfusion stays for elderly during 2011\u20132012, 2517 had FNHTR<\/jats:styled-content> diagnosis recorded, an overall rate of 58\u00b70 per 100\u00a0000 stays. FNHTR<\/jats:styled-content> rates (per 100\u00a0000 stays) varied by age, gender, number of units and blood components transfused. FNHTR<\/jats:styled-content> rates were substantially higher for RBC<\/jats:styled-content>s\u2010 and platelets\u2010containing transfusions as compared to plasma only. Significantly higher odds of FNHTR<\/jats:styled-content> were identified with greater number of units transfused (P<\/jats:italic>\u00a0<\u00a00\u00b701), for females vs. males (OR<\/jats:styled-content>\u00a0=\u00a01\u00b715, 95% CI<\/jats:styled-content> 1\u00b704\u20131\u00b727), and with 1\u2010year histories of transfusion (OR<\/jats:styled-content>\u00a0=\u00a01\u00b725, 95% CI<\/jats:styled-content> 1\u00b710\u20131\u00b742), lymphoma (OR<\/jats:styled-content>\u00a0=\u00a01\u00b722, 95% CI<\/jats:styled-content> 1\u00b702\u20131\u00b746), leukaemia (OR<\/jats:styled-content>\u00a0=\u00a01\u00b790, 95% CI<\/jats:styled-content> 1\u00b756\u20132\u00b731) and other diseases.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study shows increased FNHTR<\/jats:styled-content> occurrence among elderly with greater number of units and with RBC<\/jats:styled-content>s\u2010 and platelets\u2010containing transfusions, suggesting need to evaluate effectiveness of prestorage leucoreduction in elderly. The study also suggests importance of prior recipient alloimmunization and underlying health conditions in the development of FNHTR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12215","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T04:13:46Z","timestamp":1417666426000},"page":"251-261","source":"Crossref","is-referenced-by-count":26,"title":["Febrile non\u2010haemolytic transfusion reaction occurrence and potential risk factors among the U<\/scp>.S<\/scp>. elderly transfused in the inpatient setting, as recorded in M<\/scp>edicare databases during 2011\u20132012"],"prefix":"10.1111","volume":"108","author":[{"given":"M.","family":"Menis","sequence":"first","affiliation":[{"name":"Food and Drug Administration Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Forshee","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"McKean","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gondalia","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Warnock","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Worrall","sequence":"additional","affiliation":[{"name":"Centers for Medicare & Medicaid Services Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Kelman","sequence":"additional","affiliation":[{"name":"Centers for Medicare & Medicaid Services Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Izurieta","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"57","volume-title":"Transfusion Reactions","author":"Heddle NM","year":"2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444303513.ch53"},{"key":"e_1_2_8_4_1","unstructured":"Public Health Agency of Canada.Transfusion transmitted injuries. Noninfectious Risks of Transfusion. Available from:http:\/\/www.phac-aspc.gc.ca\/hcai-iamss\/tti-it\/risks-eng.php[Last accessed 3 November 2014]"},{"key":"e_1_2_8_5_1","unstructured":"Serious Hazards of Transfusion Steering Group.Annual Serious Hazards of Transfusion (SHOT) report 2011. Available from:http:\/\/www.shotuk.org\/wp-content\/uploads\/2012\/07\/SHOTANNUAL-REPORT_FinalWebVersionBookmarked_2012_06_22.pdf[Last accessed 10 March 2014]"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/LM3NAABJJK1HNYFU"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2001.0151"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-708-NCOBT"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199911000-00012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199502060-00013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39399219278.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.331094054613.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2003.00660.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00709.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34694295059.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7368.803"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.22.1.213"},{"key":"e_1_2_8_19_1","unstructured":"CMS Baltimore"},{"key":"e_1_2_8_20_1","unstructured":"Files for Order \u2010 General Information [monograph on the Internet].Baltimore:CMS; [updated 2013 Apr 23]. Available from:http:\/\/www.cms.gov\/Research-Statistics-Data-and-Systems\/Files-for-Order\/FilesForOrderGenInfo\/index.html[Last accessed 10 February 2014]"},{"key":"e_1_2_8_21_1","volume-title":"International Classification of Diseases","author":"Hart AC","year":"2010"},{"key":"e_1_2_8_22_1","unstructured":"AABB billing guide for transfusion & cellular therapy services [monograph on the Internet].Bethesda MD American Association of Blood Banks 2007October. Available from:http:\/\/www.aabb.org\/advocacy\/reimbursementinitiatives\/Documents\/reimbguidev071017.pdf[Last accessed 12 June 2014.]"},{"key":"e_1_2_8_23_1","unstructured":"Inpatient RIF: Data Documentation [database on the Internet].Minneapolis MN Research Data Assistance Center (ResDAC); c2013. Available from:http:\/\/www.resdac.org\/cms-data\/files\/ip-rif\/data-documentation[Last accessed 10 February 2014]"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5525"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/80.1.27"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.pan.a004868"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0700700103"},{"key":"e_1_2_8_32_1","first-page":"33","article-title":"A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions","volume":"6","author":"Anderson NA","year":"1996","journal-title":"Transfus Med"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2005.00546.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0041-1132.2003.00518.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2003.08.013"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0041-1132.2004.00608.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0041-1132.2004.00609.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36196190511.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12626"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12070"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03535.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12782"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.15.1950"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.15.1941"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:56:26Z","timestamp":1696020986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/vox.12215"],"URL":"https:\/\/doi.org\/10.1111\/vox.12215","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,3]]}}}