{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:12Z","timestamp":1791296652661,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion\u2010associated circulatory overload (<jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>) is the second leading cause of reported transfusion\u2010related fatalities in the United States. While its occurrence has been previously investigated after red cell and plasma transfusion, no data are available regarding its association with platelet transfusion. Our goal was to determine the rate of platelet\u2010associated <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> at our university medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>This study had retrospective and prospective analyses. The 13\u2010year retrospective analysis served to determine the historical rate of platelet\u2010associated <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> by passive reporting. The 30\u2010day prospective analysis included active surveillance of all non\u2010emergently issued and non\u2010operative platelet recipients \u226516\u00a0years old with no transfusions in the previous 6\u00a0h determined by analysis of blood bank product issue records. Data collected included demographics, vital signs pre\u2010 and posttransfusion, fluid balances, supplemental oxygen use, reports of dyspnoea, and infusion rates. For the prospective analysis, all variables were collected within 24\u00a0h of transfusion from the medical record and, when necessary, interviews with care providers and\/or patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the retrospective analysis, 366 reactions were reported, of which 6 (1\u00b76%) were <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>. The historical rate of <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> was 1:5997 transfused platelet units. During the prospective analysis, 225 eligible patients received a total of 334\u00a0units of platelets. The average platelet transfusion volume was 261\u00a0\u00b1\u00a026\u00a0ml, and the average infusion rate was 391\u00a0\u00b1\u00a0198\u00a0ml\/h. Two unreported <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> reactions were discovered and characterized by new\u2010onset hypertension, crackles on lung auscultation, dyspnoea, hypoxia and supplemental oxygen requirements which resolved completely with diuresis. The rate of <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> during this prospective analysis was 1:167 transfused platelet units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet\u2010associated <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> is greatly underestimated by passive reporting in the adult patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12234","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T19:13:19Z","timestamp":1425669199000},"page":"387-392","source":"Crossref","is-referenced-by-count":58,"title":["Passive reporting greatly underestimates the rate of transfusion\u2010associated circulatory overload after platelet transfusion"],"prefix":"10.1111","volume":"108","author":[{"given":"J. S.","family":"Raval","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Mazepa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Russell","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Service University of North Carolina Hospitals Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Immel","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Service University of North Carolina Hospitals Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Whinna","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. A.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"727","volume-title":"Technical Manual","author":"Mazzei CA","year":"2011"},{"key":"e_1_2_9_3_1","first-page":"516","volume-title":"Platelet Transfusion Therapy","author":"Raval JS","year":"2013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-753"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04326.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02816.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12070"},{"key":"e_1_2_9_9_1","volume-title":"Proposed Standard Definitions for Surveillance of Non Infectious Adverse Transfusion Reactions","author":"ISBT Working Party on Haemovigilance","year":"2011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01656.x"},{"key":"e_1_2_9_11_1","volume-title":"Fatalities Reported to FDA Following Blood Collection and Transfusion: Annual Summary for Fiscal Year 2013","author":"U.S. Food and Drug Administration","year":"2013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199901000-00002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00930.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03247.x"},{"key":"e_1_2_9_15_1","unstructured":"WhitakerBI HinkinsS:The 2011 National Blood Collection and Utilization Survey Report.U.S. Department of Health and Human Services Washington D.C.2011"},{"key":"e_1_2_9_16_1","first-page":"132","article-title":"Recommendations for the transfusion of plasma and platelets","volume":"7","author":"Liumbruno G","year":"2009","journal-title":"Blood Transfus"},{"key":"e_1_2_9_17_1","first-page":"397","volume-title":"Transfusion Therapy: Clinical Principles and Practice","author":"Sesok\u2010Pizzini D","year":"2011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02748.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12454"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12056"},{"key":"e_1_2_9_21_1","first-page":"625","volume-title":"Technical Manual","author":"Sink BLS","year":"2011"},{"key":"e_1_2_9_22_1","first-page":"789","volume-title":"Transfusion Therapy: Clinical Principles and Practices","author":"Becker JL","year":"2011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.02.001"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12234","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:00:24Z","timestamp":1695502824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/vox.12234"],"URL":"https:\/\/doi.org\/10.1111\/vox.12234","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}