{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:29:18Z","timestamp":1788802158237,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>If \u2018passenger lymphocyte syndrome\u2019 (<jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content>) is a well\u2010recognized complication in <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010mismatched solid organ transplantation, the coexistence of this reaction with recipient's alloimmunization against multiple antigens expressed on the residual red blood cells in the graft is less common and unpredictable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The receiver of an <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> minor\u2010mismatch liver graft from a cadaveric donor developed haemolytic anaemia within 2 weeks after transplantation. The organ donor was of blood group O D+C+c+E+e+ K+k+ Le(a+b\u2010) and the recipient, A<jats:sub>1<\/jats:sub> D\u2010C\u2010c+E\u2010e+ K\u2010k+ Le(a\u2010b\u2010).<\/jats:p><jats:p>The donor and recipient were both tested for irregular antibodies. Elution was performed on the recipient's red blood cells (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the recipient and donor had irregular alloantibodies at the time of transplantation. On day 10, anti\u2010A antibodies were detected in the recipient's serum and eluted from his <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s. At the same time, the patient developed multiple alloantibodies: anti\u2010D, anti\u2010C, anti\u2010E, anti\u2010K and anti\u2010Le<jats:sup>a<\/jats:sup> against the donor's erythrocyte antigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although serological analysis and haemolytic parameters confirmed the diagnosis of <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> which required transfusion support, no sign of graft damage due to recipient's immune reaction was detected. This case illustrates the required follow\u2010up of the recipient after transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12253","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T19:40:54Z","timestamp":1428003654000},"page":"86-90","source":"Crossref","is-referenced-by-count":14,"title":["Simultaneous passenger lymphocyte syndrome and multiple alloimmunization against donor's blood group antigens after liver transplantation"],"prefix":"10.1111","volume":"109","author":[{"given":"M.","family":"Monfort","sequence":"first","affiliation":[{"name":"Department of Clinical Biology Laboratory of ImmunoHematology CHU Li\u00e8ge University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Honor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery and Transplantation CHU Li\u00e8ge University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gothot","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology Laboratory of ImmunoHematology CHU Li\u00e8ge University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology Laboratory of ImmunoHematology CHU Li\u00e8ge University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"4575","article-title":"Experience with primary liver transplantation across ABO blood groups","volume":"19","author":"Gordon RD","year":"1987","journal-title":"Transplant Proc"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411013111807"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29589284137.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31191096190.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282e9a576"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2000.00236.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357985"},{"key":"e_1_2_6_9_1","first-page":"25","article-title":"Transfusion management of passenger lymphocyte syndrome post liver transplantation at Leeds teaching hospitals","volume":"24","author":"Allan R","year":"2014","journal-title":"Transfus Med"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.21307\/immunohematology-2019-226","article-title":"Nonhemolytic passenger lymphocyte syndrome: donor\u2010derived anti\u2010M in an M+ recipient of a multiorgan transplant","volume":"25","author":"Makuria AT","year":"2009","journal-title":"Immunohematology"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/715769"},{"key":"e_1_2_6_12_1","volume-title":"Applied Blood Group Serology","author":"Issitt PD","year":"1985"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01045.x"},{"key":"e_1_2_6_14_1","volume-title":"Technical manual","author":"Roback JD","year":"2008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1996.tb00997.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950050242"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.00934.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41030365.x"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12253","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:29:06Z","timestamp":1696170546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,31]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/vox.12253"],"URL":"https:\/\/doi.org\/10.1111\/vox.12253","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,31]]}}}