{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:46:10Z","timestamp":1791351970399,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","award":["007\/0097"],"award-info":[{"award-number":["007\/0097"]}],"id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Background and Objectives<\/jats:title>\n \n This paper reports the results to 31 May 2015 of an ongoing\n UK<\/jats:styled-content>\n study to look for additional cases of variant Creutzfeldt\u2013Jakob disease (\n vCJD<\/jats:styled-content>\n ) transmission by blood transfusion, and to seek evidence whether other subtypes of Creutzfeldt\u2013Jakob disease (\n CJD<\/jats:styled-content>\n ) may be transmissible via blood components.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n All\n vCJD<\/jats:styled-content>\n cases of appropriate age and any sporadic\n CJD<\/jats:styled-content>\n (\n sCJD<\/jats:styled-content>\n ) or familial\n CJD<\/jats:styled-content>\n (\n fCJD<\/jats:styled-content>\n ) cases with a history of blood donation or transfusion are notified to the\n UKBS<\/jats:styled-content>\n . Donation records are sought and the usage of all donations is determined by look back. Death certificates are obtained for all donors to patients with\n CJD<\/jats:styled-content>\n and recipients of transfused components from patients with\n CJD<\/jats:styled-content>\n who are deceased.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study identified 29\n sCJD<\/jats:styled-content>\n blood donors, of 370 reported, with transfusion to 211 recipients. Five of these recipients were reported to have died with or of dementia, but were not believed to be cases of\n CJD<\/jats:styled-content>\n . The\n vCJD<\/jats:styled-content>\n arm found 18\n vCJD<\/jats:styled-content>\n blood donors who had donated blood which was issued for clinical usage, of 24 traced donors from 177\n UK vCJD<\/jats:styled-content>\n cases. To date, 3 cases of\n vCJD<\/jats:styled-content>\n have occurred in 67 recipients identified in this recipient group, and one recipient had post\u2010mortem confirmation of abnormal prion protein deposition in the spleen (all previously reported).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results of the ongoing\n TMER<\/jats:styled-content>\n study show no new cases of transfusion\u2010associated\n vCJD<\/jats:styled-content>\n since 2007 and no evidence of transfusion transmission of\n sCJD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.12371","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T14:31:02Z","timestamp":1451313062000},"page":"310-316","source":"Crossref","is-referenced-by-count":96,"title":["Creutzfeldt\u2013Jakob disease and blood transfusion: updated results of the\n UK<\/scp>\n Transfusion Medicine Epidemiology Review Study"],"prefix":"10.1111","volume":"110","author":[{"given":"P. J. M.","family":"Urwin","sequence":"first","affiliation":[{"name":"National CJD Research & Surveillance Unit Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"National CJD Research & Surveillance Unit Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Llewelyn","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant Cambridge Centre Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Will","sequence":"additional","affiliation":[{"name":"National CJD Research & Surveillance Unit Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. E.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant Colindale Centre Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801762"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00833.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16811-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03004.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03198.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02056.x"},{"key":"e_1_2_9_8_1","first-page":"57S","article-title":"Creutzfeldt\u2010Jakob disease (CJD) investigational lookback study","volume":"36","author":"Sullivan MT","year":"1996","journal-title":"Transfusion"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7105.389"},{"key":"e_1_2_9_10_1","first-page":"1","volume-title":"WHO Manual for Strengthening Diagnosis and Surveillance of Creutzfeldt\u2010Jakob disease","author":"World Health Organisation","year":"1998"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12161"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5675"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-146"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110837"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1806.120116"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt032"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2001.130353"},{"key":"e_1_2_9_18_1","unstructured":"Office for National Statistics release: Death Certification Reform: A Case Study on the Potential Impact on Mortality Statistics England and Waleshttp:\/\/www.ons.gov.uk\/ons\/rel\/subnational-health2\/death-certification-reform-a-case-study-on-the-potential-impact-on-mortality-statistics\/england-and-wales\/index.html(Released 26\/11\/2012 accessed 19\/03\/2015)"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12371","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:18:04Z","timestamp":1696033084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,28]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/vox.12371"],"URL":"https:\/\/doi.org\/10.1111\/vox.12371","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,28]]}}}