{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:44:43Z","timestamp":1761489883391},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ebola virus disease is a public health emergency of international concern, and enormous efforts are being made in the development of vaccines and therapies. Ebola virus convalescent plasma is a promising anti\u2010infective treatment of Ebola virus disease. Therefore, we developed and implemented a pathogen\u2010reduced Ebola virus convalescent plasma concept in accordance with national, European and global regulatory framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ebola virus convalescent plasma manufacture and distribution was managed by a collection centre, two medical centres and an expert group from the European Blood Alliance. Ebola virus convalescent plasma was collected twice with an interval of 61 days from a donor recovering from Ebola virus disease in Germany. After pathogen reduction, the plasma was analysed for Ebola virus\u2010specific immunoglobulin G (IgG) antibodies and its Ebola virus neutralizing activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Convalescent plasma could be collected without adverse events. Anti\u2010Ebola virus IgG titres and Ebola\u2010specific neutralizing antibodies in convalescent plasma were only slightly reduced after pathogen reduction treatment with S59 amotosalen\/<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>. A patient in Italy with Ebola virus disease was treated with convalescent plasma without apparent adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>As proof of principle, we describe a concept and practical implementation of pathogen\u2010reduced Ebola virus convalescent plasma manufacture, quality control and its clinical application to an Ebola virus disease patient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12376","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T03:36:03Z","timestamp":1452828963000},"page":"329-335","source":"Crossref","is-referenced-by-count":18,"title":["Pathogen\u2010reduced Ebola virus convalescent plasma: first steps towards standardization of manufacturing and quality control including assessment of Ebola\u2010specific neutralizing antibodies"],"prefix":"10.1111","volume":"110","author":[{"given":"C.","family":"Geisen","sequence":"first","affiliation":[{"name":"Institute for Transfusion Medicine and Immunohaematology German Red Cross Blood Donor Service Baden\u2010W\u00fcrttemberg\u2010Hessen gGmbH Goethe University Hospital Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kann","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Goethe University Hospital Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Strecker","sequence":"additional","affiliation":[{"name":"Institute of Virology Philipps University Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Goethe University Hospital Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sch\u00fcttfort","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Goethe University Hospital Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Kraaij","sequence":"additional","affiliation":[{"name":"Sanquin Blood Bank Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"MacLennan","sequence":"additional","affiliation":[{"name":"NHSBT Leeds Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rummler","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine University Hospital Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Weinigel","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine University Hospital Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Eickmann","sequence":"additional","affiliation":[{"name":"Institute of Virology Philipps University Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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