{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:24:30Z","timestamp":1761744270655,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Several transplantation outcomes have been shown to be associated with the infused bone marrow cell dose\/kg of the recipient's body weight. The donor bone marrow density is directly related to the infused cell dose. The aim of the present study was to identify donor\u2010related variables that are associated with high donor bone marrow density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We retrospectively analysed the predictive factors of high marrow density in 65 consecutive<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010haploidentical bone marrow donors harvested at our centre between 2009 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and peripheral white blood cell (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) count were directly associated with bone marrow density (regression coefficient<jats:italic>\u03b2<\/jats:italic>= 5\u00b733 and<jats:italic>\u03b2<\/jats:italic>= 2\u00b793, respectively;<jats:italic>P<\/jats:italic>&lt; 0\u00b701). The likelihood of obtaining a collection with a high density was first predicted using<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u226530, mean density = 25\u00b78<jats:styled-content style=\"fixed-case\">TNC<\/jats:styled-content>\/ml \u00d7 10<jats:sup>6<\/jats:sup>). Second, donors with a<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>&lt;30 were split into two groups according to peripheral<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>count (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>&lt;8 \u00d7 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>: mean density = 18\u00b74<jats:styled-content style=\"fixed-case\">TNC<\/jats:styled-content>\/ml \u00d7 10<jats:sup>6<\/jats:sup>;<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>\u22658 \u00d7 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>: mean density = 23\u00b71<jats:styled-content style=\"fixed-case\">TNC<\/jats:styled-content>\/ml \u00d7 10<jats:sup>6<\/jats:sup>). We also observed that the density of the first collected bag directly correlated with the overall density (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= 0\u00b769,<jats:italic>P<\/jats:italic>&lt; 0\u00b701).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The donor\u2010related features<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>count affect the cell quantity obtainable with the harvest and should be taken into account when choosing the donor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12385","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T10:11:26Z","timestamp":1456481486000},"page":"93-100","source":"Crossref","is-referenced-by-count":4,"title":["Bone marrow donor\u2010related variables associated with harvest outcome in<scp>HLA<\/scp>\u2010haploidentical transplantation with postinfusion cyclophosphamide"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-9696","authenticated-orcid":false,"given":"A.","family":"Rimondo","sequence":"first","affiliation":[{"name":"Hematology Unit Humanitas Cancer Center Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Hematology Unit Humanitas Cancer Center Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Crocchiolo","sequence":"additional","affiliation":[{"name":"Hematology Unit Humanitas Cancer Center Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Giordano","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Humanitas Cancer Center Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sarina","sequence":"additional","affiliation":[{"name":"Hematology Unit Humanitas Cancer Center Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Morabito","sequence":"additional","affiliation":[{"name":"Hematology Unit Humanitas Cancer Center Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Perotti","sequence":"additional","affiliation":[{"name":"Immunohaematology and Transfusion Service IRCCS Policlinico San Matteo Foundation Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Timofeeva","sequence":"additional","affiliation":[{"name":"Hematology Unit Humanitas Cancer Center Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Capizzuto","sequence":"additional","affiliation":[{"name":"Hematology Unit Humanitas 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