{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:02:13Z","timestamp":1784199733923,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Chronic inflammation can lead to anaemia of chronic disease due to the sequestration of iron caused by inflammatory cytokines and the protein hepcidin. However, the effect of low\u2010grade inflammation (<jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>) on haemoglobin among healthy individuals is not known. This study examines the effect of <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> on haemoglobin among Danish blood donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We performed multivariable linear regression to assess the effect of <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> (i.e. high\u2010sensitivity C\u2010reactive protein above 3 mg\/l but below 10 mg\/l) on haemoglobin in 17 322 Danish blood donors. We also performed multivariable logistic regression to evaluate the effect of <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> on the risk of having low haemoglobin (below the 10th percentile among men and women, respectively). We adjusted for donation activity, age, sex, low ferritin, oral contraceptives and menopause. All analyses were stratified by current smoking status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> was associated with lower haemoglobin (0\u00b708 m<jats:sc>m<\/jats:sc> lower [0\u00b712 g\/<jats:styled-content style=\"fixed-case\">dl<\/jats:styled-content>], 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): \u22120\u00b711\u20130\u00b705) and increased risk of low haemoglobin (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1\u00b722, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b705\u20131\u00b743) in non\u2010smokers. Conversely, <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> was associated with higher haemoglobin in smokers (0\u00b712 m<jats:sc>m<\/jats:sc> [0\u00b719 g\/<jats:styled-content style=\"fixed-case\">dl<\/jats:styled-content>], 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b706\u20130\u00b718).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this first study of <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> and haemoglobin in healthy individuals, there was a negative association between <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> and haemoglobin in non\u2010smokers. The association was positive in smokers, probably because smoking leads to both increased inflammation and increased haemoglobin through <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content> exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12396","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T21:32:47Z","timestamp":1457386367000},"page":"144-150","source":"Crossref","is-referenced-by-count":12,"title":["Low\u2010grade inflammation is associated with lower haemoglobin levels in healthy individuals: results from the Danish blood donor study"],"prefix":"10.1111","volume":"111","author":[{"given":"S. R.","family":"Kotz\u00e9","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Naestved Hospital Naestved Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. W.","family":"Th\u00f8rner","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Rigas","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Epidemiological Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rostgaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiological Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ullum","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2014.04.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.071131"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0573"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243791"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(02)00293-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.666"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20431"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533608314536"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2007.06.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20120092"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328812"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01553.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12518"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13011"},{"key":"e_1_2_8_17_1","unstructured":"WHO\/CDC. Assessing the iron status of populations: report of a Joint World Health Organization\/Centers for Disease Control and Prevention Technical Consultation on the Assessment of Iron Status at the Population Level. Geneva WHO\/CDC: 2004. [accessed Oct. 2015]. Available from:http:\/\/stacks.cdc.gov\/view\/cdc\/6681"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2009.06.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","unstructured":"ChengP JiaoX WangX et al.Hepcidin expression in anemia of chronic disease and concomitant iron\u2010deficiency anemia. Clin Exp Med [Internet]. 2010 May; Available from:http:\/\/www.springerlink.com\/index\/10.1007\/s10238-010-0102-9","DOI":"10.1007\/s10238-010-0102-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/515549"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1617-9625-10-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2179"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088196"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511005460"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309021150"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00425-9"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510410002797"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03389.x"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12396","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:58:33Z","timestamp":1696168713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,7]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/vox.12396"],"URL":"https:\/\/doi.org\/10.1111\/vox.12396","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,7]]}}}