{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:42:16Z","timestamp":1781707336673,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Individuals may donate blood in order to determine their infection status after exposure to an increased infection risk. Such test\u2010seeking behaviour decreases transfusion safety. Instances of test seeking are difficult to substantiate as donors are unlikely to admit to such behaviour. However, manifestation in a population of repeat donors may be determined using statistical inference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Test\u2010seeking donors would be highly motivated to donate following infection risk, influencing the timing of their donation. Donation intervals within 2005\u20132014 of all Dutch blood donors who acquired syphilis (<jats:italic>N<\/jats:italic> = 50), <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> (<jats:italic>N<\/jats:italic> = 13), <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content> (<jats:italic>N<\/jats:italic> = 4) or <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> (<jats:italic>N<\/jats:italic> = 2) were compared to donation intervals of uninfected blood donors (<jats:italic>N<\/jats:italic> = 7 327 836) using the Anderson\u2013Darling test. We adjusted for length bias as well as for age, gender and donation type of the infected. Additionally, the power of the proposed method was investigated by simulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the Dutch donors who acquired infection, we found only a non\u2010significant overrepresentation of short donation intervals (<jats:italic>P<\/jats:italic> = 0\u00b754). However, we show by simulation that both relatively short and long donation intervals among infected donors can reveal test seeking. The power of the method is &gt;90% if among 69 infected donors &gt;35 (51%) are test seeking, or if among 320 infected donors &gt;90 (30%) are test seeking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We show how statistical analysis may be used to reveal the extent of test seeking in repeat blood donor populations. In the Dutch setting, indications for test\u2010seeking behaviour were not statistically significant. This may, however, be due to the low number of infected individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12422","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T21:36:34Z","timestamp":1465508194000},"page":"274-280","source":"Crossref","is-referenced-by-count":6,"title":["A novel approach to detect test\u2010seeking behaviour in the blood donor population: making the invisible visible"],"prefix":"10.1111","volume":"111","author":[{"given":"A. S.","family":"de Vos","sequence":"first","affiliation":[{"name":"Transfusion Technology Assessment Unit Sanquin Research Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Lieshout\u2010Krikke","sequence":"additional","affiliation":[{"name":"Department of Blood\u2010Borne Infections Sanquin Research Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Slot","sequence":"additional","affiliation":[{"name":"Department of Blood\u2010Borne Infections Sanquin Research Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Cator","sequence":"additional","affiliation":[{"name":"Institute of Mathematics Astrophysics and Particle Physics Radboud University Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Transfusion Technology Assessment Unit Sanquin Research Amsterdam the Netherlands"},{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/tm.2000.7353"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12236"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03468.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00743.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120208629667"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12871"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2012.01643.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02650.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12809"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13298"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/5.1.145"},{"key":"e_1_2_6_13_1","unstructured":"ScholzF ZhuA:K\u2010Sample Rank Tests and their Combinations.https:\/\/cran.r-project.org\/web\/packages\/kSamples\/kSamples.pdf[Last accessed 30 May 2016]"},{"key":"e_1_2_6_14_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20208"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12125"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/01621459.1951.10500769","article-title":"The Kolmogorov\u2010Smirnov Test for Goodness of Fit","volume":"253","author":"Massey FJ","year":"1951","journal-title":"J Am Statist Assoc"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2002.00084.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00204.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01966.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00473.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13009"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:10:12Z","timestamp":1696169412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/vox.12422"],"URL":"https:\/\/doi.org\/10.1111\/vox.12422","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,9]]}}}