{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:10:23Z","timestamp":1791263423215,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International Haemovigilance Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"\n Background and Objectives<\/jats:title>\n \n The International Haemovigilance Network's\n ISTARE<\/jats:styled-content>\n is an online database for surveillance of all adverse reactions (\n AR<\/jats:styled-content>\n s) and adverse events (\n AE<\/jats:styled-content>\n s) associated with donation of blood and transfusion of blood components, irrespective of severity or the harm caused.\n ISTARE<\/jats:styled-content>\n aims to unify the collection and sharing of information with a view to harmonizing best practices for haemovigilance systems around the world.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Adverse reactionss and adverse events are recorded by blood component, type of reaction, severity and imputability to transfusion, using internationally agreed standard definitions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From 2006 to 2012, 125 national sets of annual aggregated data were received from 25 countries, covering 132.8 million blood components issued. The incidence of all\n AR<\/jats:styled-content>\n s was 77.5 per 100 000 components issued, of which 25% were severe (19.1 per 100 000). Of 349 deaths (0.26 per 100 000), 58% were due to the three\n AR<\/jats:styled-content>\n s related to the respiratory system: transfusion\u2010associated circulatory overload (\n TACO<\/jats:styled-content>\n , 27%), transfusion\u2010associated acute lung injury (\n TRALI<\/jats:styled-content>\n , 19%) and transfusion\u2010associated dyspnoea (\n TAD<\/jats:styled-content>\n , 12%). Cumulatively, 594 477 donor complications were reported (rate 660 per 100 000), of which 2.9% were severe.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ISTARE<\/jats:styled-content>\n is a well\u2010established surveillance tool offering important contributions to international efforts to maximize transfusion safety.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.12447","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T15:48:53Z","timestamp":1474559333000},"page":"409-417","source":"Crossref","is-referenced-by-count":84,"title":["The International Haemovigilance Network Database for the Surveillance of Adverse Reactions and Events in Donors and Recipients of Blood Components: technical issues and results"],"prefix":"10.1111","volume":"111","author":[{"given":"C.","family":"Politis","sequence":"first","affiliation":[{"name":"Coordinating Haemovigilance Centre (SKAE) Hellenic Centre for Disease Control and Prevention Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Wiersum","sequence":"additional","affiliation":[{"name":"TRIP National Hemovigilance and Biovigilance Office Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Panteion University of Social and Political Sciences Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Robillard","sequence":"additional","affiliation":[{"name":"Hema\u2010Quebec Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Renaudier","sequence":"additional","affiliation":[{"name":"Agence R\u00e9gionale de Sant\u00e9 Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010C.","family":"Faber","sequence":"additional","affiliation":[{"name":"LuxConsulTrans\u00ae<\/sup> Banglamung Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118338179.ch24"},{"key":"e_1_2_7_3_1","unstructured":"International Haemovigilance Network:Definition of haemovigilance. Available at:http:\/\/www.ihn-org.com\/about\/definition-of-haemovigilance\/[Last accessed 20 July 2016]"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1246-7820(01)00116-1"},{"key":"e_1_2_7_5_1","volume-title":"Haemovigilance: An Effective Tool for Improving Transfusion Safety","author":"Strengers PFW","year":"2012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01442.x"},{"key":"e_1_2_7_7_1","first-page":"215","article-title":"Is haemovigilance improving transfusion practice? The European experience","volume":"127","author":"Strengers PWF","year":"2007","journal-title":"Dev Biol"},{"key":"e_1_2_7_8_1","unstructured":"International Society for Blood Transfusion:Proposed standard definitions for surveillance of non infectious adverse transfusion reactions. July 2011. Available at:http:\/\/www.ihn-org.com\/wp-content\/uploads\/2011\/06\/ISBT-definitions-for-non-infectious-transfusion-reactions.pdf(Last accessed 20 July 2016)"},{"key":"e_1_2_7_9_1","unstructured":"European Union:Directive 2002\/98\/EC of the European Parliament and of the Council of 27 January 2003 setting standards of quality and safety for the collection testing processing storage and distribution of human blood and blood components and amending Directive 2001\/83\/EC. Official Journal of the European Union 8.2.2003:L33\/30"},{"key":"e_1_2_7_10_1","unstructured":"European Union:Commission Directive 2005\/61EC of 30 September 2005 implementing Directive 2002\/98\/EC of the European Parliament and of the Council as regards traceability requirements and notification of serious adverse reactions and events. Official Journal of the European Union 1.10.2005: L256\/32"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7237.759"},{"key":"e_1_2_7_12_1","unstructured":"International Society for Blood Transfusion:Standard for surveillance of complications related to blood donation. December 11 2014.http:\/\/www.isbtweb.org\/fileadmin\/user_upload\/files-2015\/haemovigilance\/definitions\/Revisedstandard 2014 surveillance complications related to blood donation haemovigilance.pdf (Last accessed 20 July 2016)"},{"key":"e_1_2_7_13_1","volume-title":"EDQM: Guide to the Preparation, Use and Quality Assurance of Blood Components, Recommendation R (95) 15","author":"Council of Europe","year":"2013"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"32","article-title":"The European Haemovigilance Network (EHN) database: establishment and first results","volume":"7","author":"Politis C","year":"2009","journal-title":"Blood Transf"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2011.09.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2008.00164.x"},{"key":"e_1_2_7_17_1","volume-title":"Hemovigilance: An Effective Tool for Improving Transfusion Safety","author":"Tomasulo P","year":"2012"},{"issue":"2","key":"e_1_2_7_18_1","first-page":"443","article-title":"Update on ISTARE: recent findings in recipients and future orientation of the international database on haemovigilance","volume":"12","author":"Politis C","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_7_19_1","unstructured":"SHOT:Serious Hazards of Transfusion: Annual Report 2004. 21 November 2005. 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