{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:58:27Z","timestamp":1777348707959,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fever is described in transfusion\u2010associated circulatory overload (<jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion\u2010associated atheroma disruptions).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hospital haemovigilance data (1\/1\/2010\u201331\/12\/2012) were reviewed for <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> cases (frequency and mode of referral). <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> with or without fever (<jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F\/\u2212F) was examined for its association with patient age (as a surrogate for atheroma burden) and product age (as a surrogate for storage\u2010related pyrogens). Fever in allergic transfusion reactions was also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 972 reactions, 107 suspected cases of <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> (11%) were seen. <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F vs. <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>\u2212F occurred in 42\u00b71 vs. 57\u00b79%, respectively. <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F cases were discovered in referrals to investigate either a fever (in 47\u00b71%) or dyspnoea (in 52\u00b79%). Among <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F cases, 24\u00b74% had already been febrile, whereas 75\u00b76% exhibited a new reaction\u2010associated fever. After excluding preexisting fevers, <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F occurred in 31\u00b78% of <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>, compared with 8\u00b72% of allergic reactions with fever, for an odds ratio of 5\u00b72 (2\u00b79\u20139\u00b74 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]), <jats:italic>P<\/jats:italic> &lt; 0\u00b7001. <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F\/<jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>\u2212F showed no difference in median host age (69 vs. 64 years, <jats:italic>P<\/jats:italic> = 0\u00b73), <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> age (22 days +F\/\u2212F, <jats:italic>P<\/jats:italic> = 0\u00b79) or severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transfusion\u2010associated circulatory overload disproportionately exhibits fever compared with allergic reactions. However, <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F did not associate with patient or product age, nor reflect severity. To better understand <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F, the fever\u2010congestion sequence merits attention. Further study is needed to see whether <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>+F occurs as reproducibly elsewhere, and in association with atherosclerosis in a better characterized cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12473","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T20:27:09Z","timestamp":1482352029000},"page":"70-78","source":"Crossref","is-referenced-by-count":41,"title":["The association of fever with transfusion\u2010associated circulatory overload"],"prefix":"10.1111","volume":"112","author":[{"given":"N.","family":"Parmar","sequence":"first","affiliation":[{"name":"Department of Laboratory Hematology (Blood Transfusion Laboratory [BTL]) Laboratory Medicine Program (LMP) University Health Network (UHN) Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pendergrast","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology (Blood Transfusion Laboratory [BTL]) Laboratory Medicine Program (LMP) University Health Network (UHN) Toronto ON Canada"},{"name":"Department of Medical Oncology &amp; Hematology (DMOH) University Health Network (UHN) Toronto ON Canada"},{"name":"Department of Laboratory Medicine \u2013 Pathobiology (LMP) Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Department of Medicine \u2013 Division of Hematology Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Quality, Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Collaborative Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology (Blood Transfusion Laboratory [BTL]) Laboratory Medicine Program (LMP) University Health Network (UHN) Toronto ON Canada"},{"name":"Department of Laboratory Medicine \u2013 Pathobiology (LMP) Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Quality, Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Collaborative Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology (Blood Transfusion Laboratory [BTL]) Laboratory Medicine Program (LMP) University Health Network (UHN) Toronto ON Canada"},{"name":"Department of Laboratory Medicine \u2013 Pathobiology (LMP) Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Quality, Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Collaborative Toronto ON Canada"},{"name":"Department of Clinical Pathology Blood &amp; Tissue Bank Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Callum","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology (Blood Transfusion Laboratory [BTL]) Laboratory Medicine Program (LMP) University Health Network (UHN) Toronto ON Canada"},{"name":"Department of Laboratory Medicine \u2013 Pathobiology (LMP) Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Quality, Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Collaborative Toronto ON Canada"},{"name":"Department of Clinical Pathology Blood &amp; Tissue Bank Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology (Blood Transfusion Laboratory [BTL]) Laboratory Medicine Program (LMP) University Health Network (UHN) Toronto ON Canada"},{"name":"Department of Medical Oncology &amp; 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