{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:21:26Z","timestamp":1754486486470},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma to &gt;5% of their patients, whereas another 25% transfused plasma to &lt;1% of their patients. The objective of this study was to explore the factors associated with different plasma transfusion practices in these centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Online survey sent to the local investigators of the 101 participating centres, in February 2016. Four areas were explored: beliefs regarding plasma transfusion, patients\u2019 case\u2010mix in each unit, unit's characteristics, and local blood product transfusion policies and processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The response rate was 82% (83\/101). 43% of the respondents believed that plasma transfusions can arrest bleeding, whereas 27% believe that plasma transfusion can prevent bleeding. Centres with the highest plasma transfusion rate were more likely to think that hypovolaemia and mildly abnormal coagulation tests are appropriate indications for plasma transfusions (<jats:italic>P<\/jats:italic> = 0\u00b702 and <jats:italic>P<\/jats:italic> = 0\u00b704, respectively). Case\u2010mix, centre characteristics or local transfusion services were not identified as significant relevant factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Factors influencing plasma transfusion practices reflect beliefs about indications and the efficacy of transfusion in the prevention and management of bleeding as well as effects on coagulation tests. Educational and other initiatives to target these beliefs should be the focus of research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12490","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T02:19:31Z","timestamp":1486520371000},"page":"140-149","source":"Crossref","is-referenced-by-count":6,"title":["Factors influencing plasma transfusion practices in paediatric intensive care units around the world"],"prefix":"10.1111","volume":"112","author":[{"given":"O.","family":"Karam","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit Geneva University Hospital Geneva Switzerland"},{"name":"Univ. Lille, EA 2694 \u2010 Sant\u00e9 Publique : \u00e9pid\u00e9miologie et qualit\u00e9 des soins Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Demaret","sequence":"additional","affiliation":[{"name":"Univ. Lille, EA 2694 \u2010 Sant\u00e9 Publique : \u00e9pid\u00e9miologie et qualit\u00e9 des soins Lille France"},{"name":"Pediatric Intensive Care Unit CHC Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Duhamel","sequence":"additional","affiliation":[{"name":"Univ. Lille, EA 2694 \u2010 Sant\u00e9 Publique : \u00e9pid\u00e9miologie et qualit\u00e9 des soins Lille France"},{"name":"CHU Lille Service de Biostatistique Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Shefler","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Oxford University Hospitals Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Spinella","sequence":"additional","affiliation":[{"name":"Division of Critical Care Department of Pediatrics Washington University in St Louis St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tucci","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit CHU Sainte\u2010Justine Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Leteurtre","sequence":"additional","affiliation":[{"name":"Univ. Lille, EA 2694 \u2010 Sant\u00e9 Publique : \u00e9pid\u00e9miologie et qualit\u00e9 des soins Lille France"},{"name":"CHU Lille Service de r\u00e9animation p\u00e9diatrique Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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