{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:43:23Z","timestamp":1791423803636,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prolonged storage improves availability of platelet products but could also influence safety and efficacy. This systematic review and meta\u2010analyses summarize and quantify the evidence of the effect of storage time of transfused platelets on clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search in seven databases was performed up to February 2016. All studies reporting storage time of platelet products and clinical outcomes were included. To quantify heterogeneity, <jats:italic>I<\/jats:italic>\u00b2 was calculated, and to assess publication bias, funnel plots were constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three studies reported safety outcomes and fifteen efficacy outcomes. The relative risk of a transfusion reaction after old platelets compared to fresh platelets was 1\u00b753 (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1\u00b704\u20132\u00b725) (12 studies). This was 2\u00b705 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:1\u00b747\u20132\u00b785) before and 1\u00b705 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b760\u20131\u00b784) after implementation of universal leucoreduction. The relative risk of bleeding was 1\u00b713 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b797\u20131\u00b732) for old platelets compared to fresh (five studies). The transfusion interval was 0\u00b725 days (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b713; 0\u00b738) shorter after transfusion of old platelets (four studies). Three studies reported use of platelet products: two for haematological patients and one for trauma patients. Selecting only studies in haematological patients, the difference was 4\u00b751 units (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b792; 7\u00b711).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Old platelets increase the risk of transfusion reactions in the setting of non\u2010leucoreduction, shorten platelet transfusion intervals, thereby increase the numbers of platelet transfusions in haematological patients, and may increase the risk of bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12494","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T04:53:06Z","timestamp":1488948786000},"page":"291-300","source":"Crossref","is-referenced-by-count":47,"title":["Effect of storage time of platelet products on clinical outcomes after transfusion: a systematic review and meta\u2010analyses"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1658-9257","authenticated-orcid":false,"given":"A. L.","family":"Kreuger","sequence":"first","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Caram\u2010Deelder","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jacobse","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010L.","family":"Kerkhoffs","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Department of Hematology Hagaziekenhuis Den Haag The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"van der Bom","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-7277","authenticated-orcid":false,"given":"R. A.","family":"Middelburg","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12155"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2011.01070.x"},{"key":"e_1_2_12_4_1","unstructured":"ISBTWEB:Transfusion today \u2010 quarterly newsletter of the International Society of Blood Transfusion 03\/2007; (70):9\u201010. Available from:http:\/\/www.isbtweb.org\/fileadmin\/user_upload\/Transfusion_Today\/2007\/2007-70.pdf[Last accessed 20 July 2016]"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12010"},{"key":"e_1_2_12_6_1","unstructured":"ANVISA: Resolu\u00e7\u00e3o RDC n\u00b0 57 de 16 de dezembro de 2010. Brazilian Health Surveillance Agency (Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria \u2010 ANVISA) 2010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00832.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/tm.1997.0110130"},{"key":"e_1_2_12_9_1","first-page":"135","article-title":"The effect of platelet storage time on clinical measurements: a systematic review and meta\u2010analyses","volume":"14","author":"Caram\u2010Deelder C","year":"2014","journal-title":"Vox Sang"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2004.00573.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02982.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6785.1136"},{"key":"e_1_2_12_14_1","unstructured":"A cochrane risk of bias assessment tool: for non\u2010randomized studies of interventions (ACROBAT\u2010NRSI)[Internet].2014. Available from:www.riskofbias.info[Last accessed 03 February 2016]"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01313-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/26.4.404"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112220"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_12_21_1","unstructured":"HigginsJPT GreenS:Cochrane handbook for systematic reviews of interventions. The cochrane collaboration. 2011;Version 5.1.0"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31823bdbf9"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02747.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1992.tb00035.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199911000-00012"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","unstructured":"SlichterSJ:Evidence\u2010based platelet transfusion guidelines: Hematology ASH Education Program. Washington DC ASH 2007;172\u2013178","DOI":"10.1182\/asheducation-2007.1.172"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41050691.x"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:56:33Z","timestamp":1696204593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/vox.12494"],"URL":"https:\/\/doi.org\/10.1111\/vox.12494","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]}}}